Pellicle/Saliva

most predominant protein in saliva

high affinity binding sites for?

what bonds?

alpha amylase

strep

alpha 1-4

Mucin glycoproteins: characteristic?

4 functions?

Where made?

• high MW

• Covers, protects, binds to epithelium

• Act as carriers for other proteins

• prevent dessication of mucosa

• lubricates hard and soft tissues

• Made in submandibular, sublingual, minor glands

Largest salvary protein?

MG-1: 80% carb

Histatins

Strong C albicans inhibitor

Important in wound healing in oral cavity

Statherin

Small MW

• Strongest enamel binders

• Role in lubrication

• Primary role in keeping Ca/PO4 in saliva supersaturated

Proline rich proteins

mineral homestasis

glycoslyated PRP for lubrication

30% of all salivary proteins

Cystatins

• mineral homeostasis

• Protect us from degrading ECM

• misfold → amyloid protein deposits (Alzheimers)

Secretory IgA

Critical for mucosal defense

prevents adherence to Epi

Many proteins have __ functional domains

3: enamel binding, natural antibiotic, bacterial binding

Which proteins play important role in remineralization (calcium homestasis)?

1. Stathers: in charge, keep Ca supersaturated in saliva

2. Proline rich proteins

3. Cystatins

Which salivary protein is known for antifungal?

Histatins and IgA

Which salivary proteins still show sig functional activity even after being broken down into smaller peptides

histatins: small fragments are still potent antimicrobials

statherins: smaller fragments are still highly active in bidning to enamel

Proline: unstable but fragments have wide functionality

what is it that provides salivary protein with good lubricant ability?

Carbs that can hold water/ glycosylated (have carb attached)