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Cocaine
blocks DA reuptake by DA transporter in NAc
Amphetamine
reverses the DA transporter in NAc
Cannabinoids
increase excitatory input to the VTA
Ecstasy (MDMA)
may block reuptake of DA AND inhibit those same GABAergic neurons
alcohol
includes inhibition of those same GABAergic neurons
Opiates (like heroin)
inhibit neurons that release GABA onto VTA neurons
nicotine
acts on AChRs present on the DA presyn terminals
pcp
blocks glutamate receptors in NAc (inc proj from amygdala)