effects of drugs on mesolimbic system

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8 Terms

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Cocaine

blocks DA reuptake by DA transporter in NAc 

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Amphetamine

 

reverses the DA transporter in NAc

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Cannabinoids

increase excitatory input to the VTA

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Ecstasy (MDMA)

may block reuptake of DA AND inhibit those same GABAergic neurons 

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alcohol

includes inhibition of those same GABAergic neurons 

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Opiates (like heroin)

inhibit neurons that release GABA onto VTA neurons 

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nicotine

acts on AChRs present on the DA presyn terminals

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pcp

blocks glutamate receptors in NAc (inc proj from amygdala)