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B lymphocytes (B cells)
lymphocytes that mature in the bone marrow before moving out to the blood and the rest of the body; also called B cells
interstitial fluid
fluid in the spaces between cells
lymph
clear, transparent, sometimes faintly yellow fluid that is collected from tissues throughout the body and flows in the lymphatic vessels
lymph nodes
small, bean-shaped structures found along the lymphatic vessels throughout the body
macrophages
cells that phagocytize (surround and destroy) foreign cells, such as bacteria and viruses
mucosa-associated lymphatic tissue (MALT)
lymphatic tissue found in mucous membranes that line passageways open to the outside world; these include the respiratory, gastrointestinal, urinary, and reproductive tracts
natural killer (NK) cells
lymphocytes that play an important role in the nonspecific defense system of the body by killing virus-infected cells and cancer cells
pathogens
disease-causing agents
spleen
the largest lymphatic organ in the body, located in the abdomen below the diaphragm; filters blood and activates an immune response if necessary
T lymphocytes (T cells)
lymphocytes that complete their maturation in the thymus before they move out to the blood and the rest of the body; also called T cells
complement proteins
proteins in the blood that work with immune system cells and antibodies to defend the body against infection
interferons
proteins released by cells that have been infected with viruses; interfere with virus reproduction
phagocytosis
the process by which a cell engulfs and destroys foreign matter and cellular debris
pyrogens
chemicals that tend to cause fever by raising the set-point temperature of the neurons in the hypothalamus
active immunity
immunity in which the blood plasma cells in the body make antibodies as a result of previous exposure to a disease or a vaccine
antigen-presenting cells (APCs)
cells that process protein antigens and present them on their surface in a form that can be recognized by lymphocytes (white blood cells)
apoptosis
a programmed process of cellular self-destruction (cell suicide)
cellular immunity
immunity that arises from the activation of T lymphocytes (T cells) by antigen-presenting cells; cell-mediated immunity
clonal selection
repeated division of a lymphocyte that produces many exact genetic copies of itself
humoral immunity
immunity associated with free antibodies that circulate in the blood: antibody-mediated immunity
immunoglobulins
antibodies; proteins that recognize particular antigens with great specificity
interleukins
chemicals released by helper T cells and other cells that stimulate an immune response
major histocompatibility complex glycoproteins (MHCs)
family of proteins found on the surfaces of lymphocytes and other cells; help the immune system recognize foreign antigens and ignore “self” tissues
passive immunity
immunity that comes from antibodies received from an outside source, such as breast milk
anaphylaxis
a severe and potentially life-threatening allergic reaction that may include airway obstruction and very low blood pressure
autoimmune disorder
a condition in which the immune system attacks the body’s own tissue