moa with generic/brand

sodium bicarb

raises blood and urinary ph

magnesium sulfate

decreases neuromuscular excitability

potassium chloride

nerve impulse conduction

evolocumab

inhibits pcsk9 to increase ldlr and clear ldl

ezetimibe

blocks npc1l1 to lower cholesterol absorption

fenofibrate

ppar alpha agonist, lowers apo C III and raises apo A I, lowers TG

alteplase

converts plasminogen to plasmin, breaks down clot

warfarin

inhibits VKOR to lower II, VII, IX, X

argatroban

activates V, VIII, XIII, inhibits thrombin and fibrin

heparin sodium

activates antithrombin III, inhibits thrombin, blocks fibrin

adenosine

slows AV node conduction, increases blood flow

amiodarone

inhibits K channels

flecainide

blocks Na channels (I C)

nitroglycerin

NO activates guanylate cyclase, vasodilates

isosorbide mononitrate

NO activates guanylate cyclase, vasodilates

hydralazine

vasodilate, inhibit Ca release

atropine

blocks ACh, increases HR, decreases secretions

vasopressin

V1 - increase BP

V2 - increase water reabsorption

labetalol

blocks alpha 1, beta 1, beta 2

norepinephrine

alpha 1, beta 1, alpha 2 agonist

clonidine

lowers sympathetic tone, BP, NE

doxazosin

vasodilates - lowers BP, TPR, and relaxes smooth muscle

brimonidine

alpha 2 agonist

phenylephrine

alpha 1 agonist

naphazoline

alpha 1 agonist

insulin

stimulates glucose uptake

pioglitazone

improves cell response to insulin

-gliflozin

inhibits sglt2 in proximal tubule

-glutide

glp-1 agonist

sitagliptin

dpp4 inhibitor, prolongs incretin

metformin

decreases glucose production

rizatriptan

serotonin agonist, vasoconstriction

melatonin

binds MT1A, inhibits adenylate cyclase, activates PLC, releases arachidonate

zolpidem

benzo receptor agonist

buspirone

serotonin agonist

haloperidol

blocks D2 receptors

risperidone

increases DA release, blocks serotonin receptors

trazodone

inhibits 5HT 1A and 2A reuptake, blocks H1 and alpha 1

mirtazepine

alpha 2 antagonist; increased serotonin and NE release

nortriptyline

inhibits serotonin and NE reuptake

memantine

NMDA antagonist of glutamate receptors

donepezil

inhibits AChE

divalproex

increases GABA availability

topiramate

blocks AMPA/glu receptors and Na channels

increases GABA activity

lamotrigine

inhibits glutamate release and Na channels

oxcarbazepine

blocks Na channels

levetiracetam

binds SV2A