Anaplerotic reactions

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5 Terms

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Anaplerotic reactions

Intermediates in the citric acid cycle can be usedin biosynthetic pathways (removed from cycle). The intermediates need to be replenished to continue

2
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Pyruvate + HCO3 + ATP with enzyme pyruvate carboxylase

oxaloacetate + ADP + Pi

Liver/Kidney

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Phosphoenolpyruvate + CO2 + GDP with enzyme PEP carboxylkinase

oxaloacetate + GTP

Heart/Skeletal Muscle

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Phosphoenolpyruvate + HCO3 with enzyme PEP carboxylase

oxaloacetate + Pi

Higher plants/yeast/bacteria

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Pyruvate + HCO3 + NAD(P)H with enzyme malic enzyme

malate + NAD (p)+

Eukaryotes and bacteria