Drug Solubility and Dissolution Phenomena
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9 Terms
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So
Intrinsic solubility, the saturation concentration of unionized drug
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St
Total solubility
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Si
Solubility of ionized drug
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How do you find the total solubility (St) of a weakly acidic drug?
St = So[1 + 10^(pH - pKa)]
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How do you find the total solubility (St) of a weakly basic drug?
St = So[1 + 10^(pKa - pH)]
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How do you find the precipitation pH of a weakly acidic drug?
pH = pKa + log ([St - So] / [So])
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Is the precipitation pH of a weakly acidic drug the minimum or maximum?
Minimum
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How do you find the precipitation pH of a weakly basic drug?
pH = pKa + log ([So] / [St - So])
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Is the precipitation pH of a weakly basic drug the minimum or maximum?
Maximum
Note 
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