Chpt. 18: Amines and Amides

what is an amine?

nitrogen atom

• “-e” → “-amine”

• N- when methyl attached

naming aromatic amine? (benzene + amine)

N- “-aniline”

properties of amine?

• middle BP (highest 1, lowest 3)

• high solubility

• solid @ 25

• very polar (H-bonds only with 1/2)

amine reaction as base with H2O?

“-ammonium ION”

amine reaction as acid with HCl?

“-ammonium salt”

what is a heterocyclic amine?

• in nucleic acids

• 5-/6- ring

• almost like benzene

what are alkaloids?

• plant produced

• habit forming (addiction)

• anti-depressants

what is an amide?

• nitrogen atom + = O

• heating carboxylic acid + ammonium/amine (1/2)

• “-oic acid” → “-amide”

properties of amide?

• soluble 1-5 C

• solid @ 25 C (except methanamide)

• 1 / 2 = H bonds

• MP = 1, 2, 3 (1 being highest)

acid hydrolysis of amide?

… + H2O + HCl

base hydrolysis of amide?

… + NaOH

amide in health: what is urea?

• excreted in urine

• end product of protein metabolism