myeloproliferative neoplasms chapter 32

chronic myelogenous leukemia characteristic

overproduction of myeloid cells (neutrophils)

chronic myelogenous leukemia has a positive

philadelphia chromosome

what does a positive philadelphia chromosome lead to

formation of BCR-ABL

which translocation is present in CML

t (9;22)

how can you differentiate between CML and leukemoid reaction

CML has a decreased LAP, leukemoid reaction has an increased LAP

polycythemia vera mutation in

JAK2 gene

polycythemia vera treatment

therapeutic phlebotomy

essential thrombocythemia characteristics

increased platelets, megakaryopoiesis

primary myelofibrosis

increased platelets in bone marrow

primary myelofibrosis peripheral blood

dacrocytes (teardrops), nRBCs

chronic neutrophilic leukemia

increased neutrophils with toxic granules

chronic eosinophilic leukemia

increased mature eosinophils

a peripheral blood film that shows increased neutrophils, basophils, eosinophils, and platelets is highly suggestive of

CML

which of the following chromosome abnormalities is associated with CML

t (9;22)

a patient in whom CML has previously been diagnosed has circulating blasts and promyelocytes that total 30% of leukocytes. the disease is considered to be in what phase

transformation to acute leukemia

the most common mutation found in patients with primary PV is

JAK2 V617F

the peripheral blood in PV typically manifests

erythrocytosis, thrombocytosis, and granulocytosis

complications of ET include all of the following except

infections

which of the following patterns is characteristic of the peripheral blood in patients with PMF

teardrop shaped erythrocytes, immature granulocytes, nucleated RBCs

the myelofibrosis associated with PMF is a result of

enhanced activity of fibroblasts as a result of increased stimulatory cytokines