listening, usually with a stethoscope, to gain medical information
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percussion
tapping to gain medical information
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cadaver dissection
cutting and separating human body tissues to reveal tissue relationships; gross anatomy class in grad school
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comparative anatomy
study of multiple species to learn about form, function, and evolution
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medical imaging
viewing the inside of the body without surgery
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radiology
branch of medicine concerned with imaging
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radiography (x-ray)
oldest method; high radiation power; dense tissues (bone) appear white; over half of all medical imaging
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radiopaque substances
injected or swallowed; fills hollow structures (blood vessels/intestinal tract) to show soft tissue abnormalities
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computed tomography (CT scan)
low intensity x-rays and computer analysis; low radiation power
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Magnetic Resonance Imaging (MRI)
superior quality to CT scans; best for soft tissues; flips polarity of electrons and when flipped back they emit radio waves which are used to create the images
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position emission tomography (PET scan)
accesses metabolic state of tissue; distinguishes tissues most active at a given moment; mechanics→inject radioactively labeled glucose
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sonography
ultrasounds; second oldest and second most widely used; high frequency sound waves echo back from internal organs (echolocation); avoids harmful x-rays (radiation)
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gross anatomy
study of structure that can be see with the naked eye; cadavers; no microscopes; gross=big
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histology
examination of tissues with microscope; histo=cell/tissue
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cytology
study of structure and function of cells; cyto=cells
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the hierarchy of complexity
organisms composed of organ systems composed of organs composed of tissues composed of cells composed of organelles composed of molecules composed of atoms
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anatomical variation
no two humans are exactly alike; anatomy books use most common organization
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situs inversus
left to right reversal of organ placement
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Organization (Characteristics of life)
living things exhibit a higher level of organization than nonliving things
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cellular composition (Characteristics of life)
living matter is always compartmentalized into one or more cells
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metabolism (Characteristics of life)
internal chemical reaction
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responsiveness (Characteristics of life)
ability to sense and react to stimuli; irritability or excitability
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homeostasis (Characteristics of life)
maintaining relatively stable internal conditions
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development (Characteristics of life)
differentiation and growth
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reproduction (Characteristics of life)
producing copies of themselves; passing genes to offspring
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aging
all changes occurring in the body with the passage of time; growth; development, and degenerative changes that occur later in life
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senescence
the degeneration that occurs in organ systems after the age of peak functional efficiency; gradual loss of reserve capacities, reduced ability to repair damage and compensate for stress, and increased susceptibility to disease; cause is unclear
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resistance
exercise that reduces bone fractures by putting stress on skeletal system which then causes denser bone
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endurance
exercise that reduces body fat and increases cardiac output and oxygen uptake
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life expectancy
average length of life in a given population
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life span
maximum age attainable by humans; currently 122 years
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negative feedback
allows for dynamic equilibrium within a limited range around a set point; response is opposite of the stimulus
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receptor
structure that sense change in the body
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integrating (control) center
processes the sensory information, “makes a decision”, and directs the response
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effector
cell or organ that carries out the final corrective action to restore homeostasis.
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positive feedback
self-amplifying cycle = leads to greater change in the same direction; response is the same as the stimulus; feedback loop is repeated; ex. childbirth, blood clotting
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gradient
a difference in chemical concentration, charge, temperature, or pressure between two points; matter and energy tend to flow down gradients (high→ low)
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minerals
organic elements extracted from soil by plants and passed up the food chain to humans; no carbon; 4% of body weight; important for enzyme function
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electrolytes
mineral salts needed for nerve and muscle function; minerals in water dissolve to ions; substances that ionize in water and form solutions capable of conducting electrical current
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hydrogen bond
a weak attraction between a slightly positive hydrogen atom in one molecule and a slightly negative oxygen atom of another
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hydrophilic
substances that dissolve in water; polar; water loving
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hydrophobic
substances that do not dissolve in water; nonpolar; water fearing
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acid
a proton donor; releases H+ ions in water; H+>OH-; increase in hydrogen ions = decrease in pH
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base
a proton acceptor; accepts H+ ions, releases OH- ions; H+
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kinetic energy
energy of motion
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potential energy
energy stored in an object, but not currently doing work
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chemical energy
potential energy in molecular bonds
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catalyst
lowers activation energy; speeds up reaction without increasing the temperature
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enzyme
biological catalyst in human body; protein
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macromolecules
very large organic molecules with high molecular weights
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polymers
macromolecules made of a repetitive series of identical or similar subunits
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monomers
subunits of polymers
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polymerization
joining monomers to form a polymer
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hydrolysis
digestion of covalent bonds linking monomers; water molecule added to ionize (break apart) the bond
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dehydration synthesis
how living cells form polymers; removal of a single water molecule creates bond between two monomers; water is a by product
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carbohydrates
hydrophilic organic molecules; energy source = all digested converted to glucose
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monosaccharides
one sugar
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glucose
most important to human body; six-sided ring; monosaccharide
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galactose
6-sided ring; monosaccharide
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fructose
5-sided ring; monosaccharide
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disaccharides
sugar made of two monosaccharides
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sucrose
disaccharide; table sugar
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lactose
disaccharide; sugar in milk
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maltose
disaccharide; sugar in grain products
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polysaccharides
long chains of monosaccharides (at least 50)
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glycogen
energy stored in cells of liver, muscle, brain, uterus, and vagina; naturally in humans
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starch
energy storage in plants that is digestible by humans; not naturally in humans
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cellulose
structural molecule in plants that is important for human dietary fiber but is not digestible by us
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lipids
hydrophobic organic molecules with a high ration of hydrogen to oxygen; high caloric density = more calories per gram than carbs
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triglycerides
neutral fats; three fatty acids linked to glycerol; at room temperature liquid= unsaturated (oil) solid= saturated (lard); energy storage, insulation and shock absorption; endocrine tissue
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trans-fatty acids
related to heart disease
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cis-fatty acids
higher energy state; easy to remove from the body; bent
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phospholipids
similar to triglycerides but one of the fatty acids is replaced by a phosphate group
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amphipathic
fatty acid “tails” are hydrophobic, phosphate “head” is hydrophilic.
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phospholipid bilayer
structural foundation of cell membrane
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steroid
a lipid with 17 carbon atoms in four rings; cholesterol, cortisol, progesterone, testosterone; lipids
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cholesterol
the “parent” steroid from which the other steroids are synthesized; nervous system function and structural integrity of cell membrane
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Protein
a polymer of amino acids
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conformation
unique, three-dimensional shape of protein crucial to function
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denaturation
extreme conformational change that destroys function; caused by extreme heat or pH
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primary (protein) structure
sequence of amino acids which is encoded in the genes
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secondary (protein) structure
coiled or folded shape held together by covalent peptide bonds; alpha helix= spring-like shape; beta helix= pleated, ribbon-like sheets
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tertiary (protein) structure
further bending and folding of alpha and beta helixes; hydrophobic-hydrophilic interaction
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quaternary (protein) structure
associations of two or more polypeptide chains due to ionic bonds and hydrophobic-hydrophilic interactions; not all proteins reach this structure; hemoglobin
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protein function
structure, communication, membrane transport, catalysis (enzymes), recognition and protection, movement, and cell adhesion
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nucleic acids
polymer of nucleotides; information storage and transfer
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deoxyribonucleic acid (DNA)
storage; contains millions of nucleotides; constitutes genes; instructions for protein synthesis; double stranded = more stable
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ribonucleic acid (RNA)
messenger, ribosomal, and transfer; carries out genetic instruction for protein synthesis; single stranded
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adenosine triphosphate (ATP)
most important energy transfer molecule; stores energy gained from exergonic) reactions; energy currency (fast like “cash in hand”)
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cell theory
all organisms composed of cells and cell products; cell is the simplest structural and functional unit of life; structure and function are due to activities of cells; cells come only from preexisting cells; biochemical similarities
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squamous
thin, flat, scaly cells
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cuboidal
square-is looking cells
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columnar
cells that are taller than they are wide
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light microscope
revealed plasma membrane, nucleus, and cytoplasm
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transmission electron microscope
improved resolution; ability to reveal detail
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scanning electron microscope
improved resolution further but only for surface features