Apomorphine for ED Is It Worth a Try?

Apomorphine

A direct dopamine receptor agonist used to treat erectile dysfunction (ED) by stimulating dopamine receptors in the brain.

Mechanism of Action

Apomorphine activates dopamine D1 and D2 receptors in the hypothalamus and ventral tegmental area to increase penile blood flow and facilitate erections.

Dosage

Recommended starting dose of apomorphine for ED is 2 mg, taken sublingually 25-30 minutes before sexual activity.

Efficacy

Clinical trials show apomorphine is effective in approximately 60-70% of cases, especially in psychogenic ED.

Apomorphine vs. PDE5 Inhibitors

Apomorphine is best for psychogenic ED or when PDE5 inhibitors fail; PDE5 inhibitors are more effective for physically rooted ED.

Side Effects

Common side effects of apomorphine include nausea, dizziness, yawning, and nasal congestion.

Contraindications

Apomorphine should be avoided in patients with severe orthostatic hypotension, cardiovascular disease, or hypersensitivity to dopamine agonists.

Administration

Apomorphine is administered sublingually, allowing for rapid absorption, typically working within 25 minutes.

Effect on Psychogenic ED

Apomorphine is particularly effective for erectile dysfunction caused by psychological factors such as anxiety or stress.

Clinical Trials

A landmark 2001 study found that 68% of men with psychogenic ED achieved sufficient erections after taking apomorphine.