NMJ Steps

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13 Terms

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Motor neuron depolarization

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Action potential travels down axon to NMJ

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AP cause Ca2+ ions to influx into synaptic bulb

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ACh is released into synaptic cleft

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ACh binds to receptors on muscle cells sarcolemma

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Na+ ion channels in sarcolemma open

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Depolarization of sarcolemma occurs

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AP travels down T-tubules

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Ca2+ is released from terminal cisternae

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Ca2+ ions influx into sarcoplasm

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Ca2+ binds to troponin

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Tropomyosin is moved on the actin fibers

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Myosin binding sites on actin are exposed