Adaptive immunity (Antibodies) (After midsem)

What is the first line defense of the body

Innate immunity

Which immunity has memory

Adaptive immunity

Which cells produce antibodies

Plasma cells

Where do T cells mature

Thymus

Where do B cells mature

Bone marrow

Which organ filters blood

Spleen

Which organ filters lymph

Lymph node

Which cells are professional APCs

Dendritic cells macrophages B cells

Which cytokine causes fever

IL 1

Which cytokine induces acute phase proteins

IL 6

Which cytokine activates macrophages

IFN gamma

Which cytokine promotes T cell growth

IL 2

Which cells kill virus infected cells

Cytotoxic T cells

Which cells help B cells

Helper T cells

Which cells suppress immunity

Regulatory T cells

Which cells mediate ADCC

NK cells

What is humoral immunity

Antibody mediated immunity

What is cell mediated immunity

T cell mediated immunity

Which antibody activates complement strongly

IgM

Which antibody crosses placenta

IgG

Which antibody is mucosal

IgA

Which antibody mediates allergy

IgE

Which antibody is BCR on naive B cells

IgM IgD

Which receptor recognizes Fc region

Fc receptor

What is opsonization

Coating pathogen for phagocytosis

Which complement fragment is major opsonin

C3b

Which complement fragment causes chemotaxis

C5a

Which complement fragment is anaphylatoxin

C3a C5a

What forms MAC

C5b C6 C7 C8 C9

What is MAC

Membrane attack complex

Which MHC is on all nucleated cells

MHC class I

Which MHC is on APCs

MHC class II

MHC I presents to which cells

CD8 T cells

MHC II presents to which cells

CD4 T cells

Peptide length in MHC I

8 to 10 amino acids

Peptide length in MHC II

13 to 18 amino acids

Which chromosome contains HLA complex

Chromosome 6

Human MHC is called

HLA

Mouse MHC is called

H 2

What is beta 2 microglobulin associated with

MHC class I

Which pathway presents endogenous antigen

Cytosolic pathway

Which pathway presents exogenous antigen

Endocytic pathway

Which complex degrades endogenous proteins

Proteasome

What tags proteins for degradation

Ubiquitin

Which cells activate naive T cells best

Dendritic cells

What is BCR

Membrane bound antibody

What is TCR

T cell receptor

TCR recognizes antigen with

MHC

CD4 binds which MHC

MHC class II

CD8 binds which MHC

MHC class I

Which receptor complex signals with TCR

CD3

What are CDRs

Complementarity determining regions

Which fragment binds antigen

Fab

Which fragment binds Fc receptors

Fc

Pepsin digestion gives

F ab prime 2

Papain digestion gives

Fab and Fc

Which antibody has highest avidity

IgM

Affinity means

Strength of single Ag Ab interaction

Avidity means

Total strength of multivalent binding

What is monoclonal antibody

Antibody from single clone

Who developed hybridoma

Kohler and Milstein

Hybridoma is fusion of

B cell and myeloma cell

What is ADCC

Antibody dependent cell mediated cytotoxicity

Which cells perform ADCC mainly

NK cells

What is cross reactivity

Antibody binding similar epitope

What is specificity

Ability to bind exact antigen

What is immunologic memory

Faster secondary response

What is self nonself recognition

Distinguishing own from foreign

What is antigen

Molecule recognized by immune system

What is epitope

Antigenic determinant

What is paratope

Antigen binding site on antibody

What is immunoglobulin fold

Beta sheet sandwich domain

What is cytokine storm

Excess cytokine release

What is PAMP

Pathogen associated molecular pattern

What is PRR

Pattern recognition receptor

What does poly I C mimic

Viral dsRNA

What is innate immunity

Rapid non specific immunity

What is adaptive immunity

Specific memory immunity

Which cells are granulocytes

Neutrophils eosinophils basophils

Which cells are agranulocytes

Lymphocytes monocytes

Which cells release histamine

Basophils mast cells

Parasite infection

Eosinophils

Which cells become macrophages

Monocytes

Resident tissue phagocyte

Macrophage

Strongest APC

Dendritic cell

Which antibody is secreted in mucosa

IgA

Which receptor transports IgA

Poly Ig receptor

Which receptor transports IgG placenta

FcRn

What is clonal expansion

Antigen specific proliferation

What are plasma cells

Antibody secreting B cells

What are memory B cells

Long lived recall cells

What are memory T cells

Long lived T recall cells

Which cells produce IFN gamma

TH1 NK cells

Which TH subset helps macrophages

TH1

Which TH subset helps B cells and allergy

TH2

Which TH subset recruits neutrophils

TH17

Which TH subset suppresses immunity

Treg

What is MHC restriction

TCR recognizes antigen only with self MHC

Which cells express B7 costimulator

Activated APCs