Immune tolerance
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4 Terms
What is Central Tolerance?
Central tolerance is the removal of certain antigen-specific cells. This prevents the immune system from harming itself.
Positive selection
T cells with low affinity for antigens and MHC don’t receive survival signals (neglect)
Negative selection
Removal of T cells that bind too strongly through signals for apoptosis
Explain Peripheral Tolerance
Peripheral Tolerance is the mechanisms which ensure T cells do not activate inappropriately.
Binding of CD80/CD86 (B7-1/B7-2) to CTLA-4 which turns off activated T cells. CTLA-4 is an immune checkpoint.
Treg cells secrete cytokines (IL10 and TGF-beta) to inhibit self reactive T cells. Important after infection has been cleared.
Name an example of antigen segregation.
Blood brain barrier.
What happens when immune tolerance fails?
Allergies
Autoimmunity
Immunodeficiency
Note 
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