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Hydroxyl
-OH
Polar
Neutral
Found in: Sugars, Alchols
Function: increases water solubility, enables hydrogen bonding
Methyl
-CH3
Nonpolar
Neutral
Found in: DNA, lipids
Function: hydrophobic
Carbonyl
C=O
Polar
Neutral
Found in: Sugars
Function: Adds polarity
Carboxyl
-COOH
Acidic
Acid (can donate H+)
Found in: Amino Acids, fatty acids
Amino
-NH2
Basic
Base (can accept H+)
Found in: Amino Acids, proteins
Function: Acts as a base, accepts H⁺
Phosphate
-PO42-
Acidic
Acid
Found in: ATP, DNA/RNA, phospholipids
Function: Energy transfer, negative charge, signaling
Sulfhydryl
-SH
Polar
Neutral
Found in: Proteins
Function: disulfide bonds → stabilizes protein structure