Antimicrobials Charts

What drug class inhibits cell wall biosynthesis by targeting the penicillin binding proteins?

β lactams:

penicillins

cephalosporins

monobactams

carbapenems

What drug class inhibits cell wall biosynthesis by targeting the peptidoglycan subunits?

glycopeptides

What drug class inhibits cell wall biosynthesis by targeting the peptidoglycan subunits transport?

bacitracin

What drug class inhibits biosynthesis of proteins by targeting the 30s ribosomal subunit? (2)

aminoglycosides

tetracyclines

What drug class inhibits biosynthesis of proteins by targeting the 50s ribosomal subunit? (4)

macrolides

licosamides

chloramphenicol

oxazolidinones

What drug class disrupts the membrane by targeting the lipopolysaccharide, inner and outer membrane? (3)

Polmyxin B

Colistin

daptomycin

What drug class inhibits nucleic acid synthesis by targeting RNA?

rifamycin

What drug class inhibits nucleic acid synthesis by targeting DNA?

Fluroquinolones

What drug class uses antimetabolites by targeting folic acid synthesis enzyme? (2)

sulfoamides

trimethoprim

What drug class uses antimetabolites by targeting mycolic acid synthesis enzyme?

isonicotinic acid hydrazide

What drug class uses mycobacterial ATP synthase inhibitor by targeting mycobacterial ATP synthase?

Diarylquinoline

What is the MOA for Rifamycin?

inhibits bacterial RNA poly activity and blocks transcription which kills the cell

What is the MOA of Fluroquinolones?

inhibits the activity of DNA gyrase and blocks DNA replication and kills the cell

What is the MOA of Amingioglycosides?

What do they target?

causes mismatches between codons and anticodons leading to faulty proteins that insert and disrupts cytoplasmic membrane

30s subunit

What is the MOA of tetracyline?

What do they target?

block association of tRNA with ribosome

30s subunit

What is the MOA for Macrolides and Lincosamides?

What do they target?

blocks the peptide bond formation between amino acids

50s subunit

What is the MOA of Oxazolindinones?

What doe they target?

interferes w the formation of the initiation complex between 50s and 30s subunits

50s subunit

What is the MOA for Polymyxins?

binds to LPS in outer membrane which then disrupts the membrane integrity

What is the MOA for Monobactams?

inhibits PBP3 which blocks cell wall synthesis

What is the MOA of Marbapenems?

inhibits PBPs which blocks cell wall synthesis

What are the THREE antibiotics that are G+ specific?

Narrow spectrum penicillins

anti-staph penicillins

Glycopeptides

What are the FOUR antibiotics that are G- specific?

Polymyxins

Monobactams

Aminoglycosides

Ciprofloxacin

What is the MOA for Metronidazole?

Reduced in anaerobes → DNA strand breaks

What is the MOA of Aztreonam?

Inhibits PBP3 → blocks cell wall synthesis