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What is gas exchange
Exchange of CO2 and O2 at cells and tissues through diffusion
List 5 adaptations of gas exchange surfaces
Large surface area
Thin tissue layer (1 cell thick)
Permeable membranes
Dense network of capillaries with constant blood flow surrounding to maintain concentration gradient for diffusing gases
Covered in layer of moisture: allows gas to dissolve and diffuse rapidly
Respiration
Release of ATP energy from organic compounds in cells.
What is partial pressure? What factors affect it
Pressure exerted by single gas when its found in mixture of gasses
Total pressure exerted by all gas in the mixture
Concentration of target gas
Low partial pressure of O2
Low haemoglobin affinity to O2
High partial pressure of O2
High haemoglobin affinity to O2
O2 dissociation curve (x and y axis, Shape description)
Shows affinity of haemoglobin for oxygen
X axis = partial pressure
Y axis = O2 saturation of haemoglobin
Sigmoid shape
Start at low PP low saturation.
PP increase, saturation increase
High PP, curve flattens out because most haemoglobin are fully saturated
What is the max amount of O2 that can bind with 1 Haemoglobin
4
What happens to affinity for O2 when more O2 binds to 1 haemaglobin
Conformational change in shape of haemoglobin occurs
Increases affinity o
What is co-operative binding
When binding of one molecule to another facilitates the binding of another to the same molecule
O2 Partial pressure in the lungs
HIgh partial pressure. Haemoglobin becomes fully saturated
O2 Partial pressure in respiring tissue
Respiring tissue uses O2, low concentration of O2, and low Partial pressure of O2
Haemoglobin release O2, diffuse into respiring tissue to provide more O2.
CO2 modes of transport (3)
Some CO2 is bounded in haemaglobin
Small amount of CO2 dissolved in blood plasma
Most CO2 is reversibly converted to HCO2 + ion in blood cells
Difference between Foetal and Adult Haemoglobin
Foetal: 2 alpha 2 gamma haemoglobin parts
Adult: 2 alpha 2 beta