Ceutics II Quiz 5

Class II compounds in Biopharmaceutics Classification System have ____ permeability and ____ solubility.

high; low

3 multiple choice options

The dissolution rate constant ____ the diffusion coefficient in the aqueous medium.

does not depend on

3 multiple choice options

Biopharmaceutics Classification System classifies dosage forms based on ____ . Select all relevant properties.

a) disintegration

b) solubility

c) permeability

d) disaggregation

b) solubility

c) permeability

The dissolution rate constant ____ the surface area of the particle.

is proportional to

3 multiple choice options

In the Noyes-Whitney equation, the linear term cS is equal to solubility, if ____ .

there are solid particles remaining at the end of dissolution test

3 multiple choice options

Select all slow, rate-determining processes in a solid particle dissolution.

diffusion from the diffusion layer into the bulk medium

3 multiple choice options

Sort the dosage forms in the order of increasing rate of availability for absorption (i.e. the dosage form with the fastest availability at the bottom).

Column A:

1

2

3

4

Column B:

tablets

suspensions

emulsions

solutions

1 ---- tablets

2 ---- suspensions

3 ---- emulsions

4 ---- solutions

The dissolution rate constant ____ the diffusion coefficient in the diffusion layer.

is proportional to

3 multiple choice options

FDA may grant the waiver of bioavailability studies to compounds or dosage forms with high ____ . Select all applicable properties.

a) disintegration rate

b) permeability

c) solubility

d) dissolution rate

b) permeability

c) solubility

d) dissolution rate

The dissolution rate constant ____ the thickness of the diffusion layer.

is inversely proportional to

3 multiple choice options

The dissolution rate in the Higuchi kinetics ____ the diffusion coefficient in the diffusion layer.

does not depend on

3 multiple choice options

The driving force of a solid particle dissolution is the drug concentration difference between ____ .

the two interfaces of the diffusion layer

3 multiple choice options

The dissolution rate in the Higuchi kinetics ____ the drug concentration in the aqueous medium.

depends in a nonlinear way on

3 multiple choice options

Simulated Intestinal Fluid UPS may contain ____ .

a) hydrochloric acid

b) sodium chloride

c) pepsin

d) pancreatin

e) monobasic potassium phosphate

a) hydrochloric acid

d) pancreatin

e) monobasic potassium phosphate

Increasing tortuosity of granular matrix means that the pores are ____ .

more curvy

3 multiple choice options

Class I compounds in Biopharmaceutics Classification System have ____ permeability and ____ solubility.

high; high

3 multiple choice options

To increase the dissolution rate, the particle size can be decreased in the formulation process by ____ . Select all valid approaches.

a) addition of wetting agents to prevent aggregation

b) addition of diluents

c) micronization

d) addition of surfactants to prevent aggregation

a) addition of wetting agents to prevent aggregation

c) micronization

d) addition of surfactants to prevent aggregation

The dissolution rate constant ____ the volume of the particle.

does not depend on

3 multiple choice options

The dissolution rate in the Higuchi kinetics ____ the drug concentration in the matrix.

depends in a nonlinear way on

3 multiple choice options

Class III compounds in Biopharmaceutics Classification System have ____ permeability and ____ solubility.

low; high

3 multiple choice options

In the Noyes-Whitney equation, the linear term cS is lower than solubility, if ____ .

there are no solid particles remaining at the end of dissolution test

3 multiple choice options

The dissolution rate in the Higuchi kinetics ____ porosity of the granular matrix.

depends in a nonlinear way on

3 multiple choice options

For the Higuchi kinetics in granular matrices, the dissolution rate ____ tortuosity.

decreases with increasing

2 multiple choice options

Match the kinetics of dissolution with the relevant dosage form.

Column A:

zero-order dissolution

pseudo-first order (Higuchi) dissolution

first-order dissolution

Column B:

topical and transdermal dosage forms

tablets

matrix-based dosage forms

zero-order dissolution ---- topical and transdermal dosage forms

pseudo-first order (Higuchi) dissolution ---- matrix-based dosage forms

first-order dissolution ---- tablets

The dissolution rate in the Higuchi kinetics ____ the diffusion coefficient in the matrix.

depends in a nonlinear way on

3 multiple choice options

The dissolution rate in the Higuchi kinetics ____ the volume of the aqueous medium.

does not depend on

3 multiple choice options

For tablets, the release includes ____ .

a) absorption

b) dissolution

c) disaggregation

d) disintegration

c) disaggregation

d) disintegration

The dissolution rate constant ____ the volume of the aqueous phase.

is inversely proportional to

3 multiple choice options

For the Higuchi kinetics in granular matrices, the dissolution rate ____ porosity.

increases with increasing

2 multiple choice options

Sort the dosage forms in the order of increasing rate of availability for absorption (i.e. the dosage form with the fastest availability at the bottom).

Column A:

1

2

3

4

Column B:

tablets

capsules

coated tablets

enteric coated tablets

1 ---- enteric coated tablets

2 ---- coated tablets

3 ---- tablets

4 ---- capsules

Select all fast processes in a solid particle dissolution.

a) diffusion and convection inside the bulk medium

b) diffusion from the diffusion layer into the bulk medium

c) the equilibration between the solid drug and the diffusion layer

d) diffusion inside the diffusion layer

c) the equilibration between the solid drug and the diffusion layer

d) diffusion inside the diffusion layer

The dissolution rate in the Higuchi kinetics ____ tortuosity of the granular matrix.

depends in a nonlinear way on

3 multiple choice options

Select the processes that are fully controled by formulation.

a) dissolution

b) disintegration

c) absorption

d) disaggregation

b) disintegration

d) disaggregation

Select all consequences of late release from the dosage form.

a) a portion of the dose eliminated in feces

b) increased drug metabolism

c) stomach irritation

d) decreased or negligible absorption

a) a portion of the dose eliminated in feces

d) decreased or negligible absorption

Simulated Gastric Fluid UPS contains ____ .

a) hydrochloric acid

b) pancreatin

c) pepsin

d) sodium chloride

e) monobasic potassium phosphate

a) hydrochloric acid

c) pepsin

d) sodium chloride

In the USP disintegration test, complete disintegration means that there is ____ remaining on the screen.

no tablet residue with palpably firm core

3 multiple choice options

The dissolution rate in the Higuchi kinetics ____ the thickness of the diffusion layer.

does not depend on

3 multiple choice options

To increase the dissolution rate, solubility can be increased in the formulation process by ____ . Select all valid approaches.

a) addition of wetting agents

b) addition of surfactants

c) solubilizing agents

d) micronization

a) addition of wetting agents

b) addition of surfactants

c) solubilizing agents

Sort the dosage forms in the order of increasing rate of availability for absorption (i.e. the dosage form with the fastest availability at the bottom).

Column A:

1

2

3

4

Column B:

emulsions

capsules

coated tablets

solutions

1 ---- coated tablets

2 ---- capsules

3 ---- emulsions

4 ---- solutions

Sort the dosage forms in the order of increasing rate of availability for absorption (i.e. the dosage form with the fastest availability at the bottom).

Column A:

1

2

3

4

Column B:

emulsions

capsules

enteric coated tablets

tablets

1 ---- enteric coated tablets

2 ---- tablets

3 ---- capsules

4 ---- emulsions

Class IV compounds in Biopharmaceutics Classification System have ____ permeability and ____ solubility.

low; low

3 multiple choice options