Advanced Biochem Insulin Response Quiz

protein that induces bending stress when bound to Ca++ which helps fusion of vesicle/plasma membranes within Islet beta cells (and neurons)

protein that induces bending stress when bound to Ca++ which helps fusion of vesicle/plasma membranes within Islet beta cells (and neurons)

synaptotagmin

compound most directly responsible for depolarizing the Islet beta cell which rises in the cytoplasm in response to hyperglycemia

ATP

cuts out the C peptide from proinsulin

Pc1; Pc2

Depolarization-activated influx of ions causes the release of secretory vesicles from their docking sites through the action of

CaMK2

provided by AS160 to complete the GAP function of Rabs

arginine

acts on a GAP on Rab37 so as to permit secretion of insulin

HOPS

protein that induces bending stress when bound to Ca++ which helps fusion of Glut4 vesicle/sarcolemma membranes

Doc2b

membrane ---s most directly acts to fuse vesicle with plasma membranes

snare

in fatigued, working muscle deactivates AS160

AMPK

recognizes the pre- segment emerging from ribosomes translating the preproinsulin mRNA to guide them to the rER

SRP

acts to covalently link the aminoterminal B section of proinsulin to the carboxyterminal A section

PDI

organizes the assembly and movement of exocytotic vesicles which are loaded with integral Glut4 on the surface of the golgi

Rab 10

performs the arithmatic 2+2=3+1 to activate glucose uptake, glycogen breakdown, and glycolysis to provide energy for working muscle

adenylate kinase

removes the pre- segment from preproinsulin

signal peptidase

protein that assembles in cages to pinch off vesicles from organelle membranes

clathrin

protein complex which most directly maintains the membrane potential of the Islet beta cell

K-ATP-s

motor protein that moves secretory granules away from their departing site on the golgi

kinesin

secretory vesicles move through the cell cortex to the plasma membrane through --- motor proteins

myosin-5a

acts to prevent the fusion of Glut4 vesicles with the sarcolemma membrane

AS160

pumped into secretory granules to allow maturation of proinsulin

H+

depolarization causes an influx of ions from outside of the cell through

L type channels

Islet beta cell protein requiring 50X higher glucose for it to be retained than in skeletal muscle

glucokinase

docking protein for secretory vesicles at the cytoplasm/cortex boundary within the cell

synapsin

terminal kinase of the insulin-dependent wortmannin-sensitive cascade that removes the block to Glut4 insertion into the sarcolemma

Akt/PKB

20mM Km block requiring hyperglycemia to activate Islet beta cells

Glut2

organizes the assembly and movement of secretory granules into which proinsulin is packaged on the surface of the golgi

Rab37