Katzung Chapter 16 Histamine, Serotonin and the Ergot Alkaloids

Dimenhydrinate

First generation antihistamine, used for motion sickness, marked sedation

Diphenhydramine

First generation antihistamine, cold/allergy products and sedative in OTC sleep aid products

Hydroxizine

First generation antihistamine, anti-allergy product with marked sedation

Meclizine

First generation antihistamine, used for motion sickness, less sedation

Promethazine

First generation antihistamine, antiemetic, marked sedation

Chlorpheniramine

First generation antihistamine, cold/allergy products, slight sedation

Fexofenadine, Loratadine, Cetirizine

Second generation antihistamine, anti-allergy product

Sumatriptan, Almotriptan, Rizatriptan, Zolmitriptan,Eletriptan, Naratriptan, Frovatriptan

5HT1D/1B receptor agonists used for migraines

Melatonin

Food supplement promoted for sleep

Histamine

Mediator of immediate allergic and inflammatory reactions, important role in gastric acid secretions and mediator of immune function (inflammation) and chemotaxis of WBCs

Serotonin

Involved in moods and diurnal sleep cycles, vasoconstrictor in the brain

Ramelteon

Melatonin agonists for insomnia

Tasimelteon

Melatonin agonists for non 24 hour sleep-wake disorder