Pharmacology test 2 (pt.1)

a1

constriction of small muscles

a2

blocks transmitter release, decreases flow

b1

heart and kidney

b2

dilation, relaxation, blood sugar

epi (adrenaline) receptors

a1, b1,b2

epi (adrenaline) indications

anaphylaxis, vasoconstriction, cardiac arrest

epi (adrenaline) effects and considerations

hypertension, necrosis, hyperglycemia

central line prefered

treatment of necrosis

a1 agonist, phentolamine

norepi (levophed) receptors

a1, a2, b1

norepi (levophed) indications

septic shock, increased hr, hypotensive

norepi (levophed) effects and considerations

altered heart rate, necrosis

preferred central line

dopamine receptors

a1, b1

dopamine indicaitons

low: 0-3: renal

med: 3-10: cardiac

high: 10-20: nervous system

dopamine effects and considerations

tachy, necrosis

preferred central line

dobutamine receptors

b1

dobutamine indications

heart failure

dobutamine effects and considerations

tachy

decrease dose for those taking MOAIS or depressants

albuterol (ventolin) receptors

b2

albuterol (ventolin) indications

asthma, COPD

albuterol (ventolin) effects and considerations

hyperglycemia and tremors

don’t admin to those with DM

prazosin (minipress) receptors

a1 antagonist

prazosin (minipress) indicaitons

high bp, PTSD

prazosin (minipress) effects and considerations

orthostatic hypotension, reflex tachy, ejaculation issues, hypervolemia

tamsulosin (flomax) receptors

a1 antagonist

tamsulosin (flomax) indications

BPH, kidney stones, UTI

tamsulosin (flomax) effects and considerations

HA

beta blockers receptors

a1, b1, b2

beta blockers indicaitons

HTN, stage fright

beta blockers effects and considerations

respiratory distress

propranolol receptors

b1, b2 (nonselective)

metoprolol receptors

b1 (cardioselective)

carvedilol receptors

a1, b1, b2 (nonselective)

clonidine (catapress) receptors

a2

clonidine (catapress) indications

hypertension, ADHD

clonidine (catapress) effects and considerations

dry mouth, fetal harm

SLUDGE

salvation, lacrimation, urination, diarrhea, gi cramps, emesis

Killer Bs

broncocontriciton

bradycardia

bronchochorrhea

Antichollerginic effects

hot as a hare

dry as a bone

red as blood

blind as a bot

mad as a hatter

pilocarpine receptor

muscarnic

pilocarpine moa

decreases intraoccular pressure

pilocarpine indicaitons

glaucoma

pilocarpine effects and considerations

miosis, SLUDGE, BBB, seizures

bethanechol (urecholine) receptor

muscarnic

bethanechol (urecholine) moa

relaxes trigone and sphincter

bethanechol (urecholine) indicaitons

unrinary retention, GERD

bethanechol (urecholine) effects and consideraitons

SLUDGE, BBB

admin on empty stomach, don’t admin if ulcers

bethanechol (urecholine) overdose drug

atropine

atropine receptors

muscarnic antagonist

atropine moa

blocks acetocholyne

atropine indicaitons

bradycardia, overdose of ACh

atropine effects and considerations

antichollerginic effects

oxybutynin (ditropan XL) receptors

muscarnic 3 antagonist

oxybutynin (ditropan XL) moa

relaxes detruser muslce

oxybutynin (ditropan XL) indications

OAB

oxybutynin (ditropan XL) effects and considerations

antichollerginic effects, dry eye, constapation

mirabegron (myrbetriq) receptors

b3

mirabegron (myrbetriq) moa

relaxes detrusor muscles

mirabegron (myrbetriq) indicaitons

OAB

mirabegron (myrbetriq) effects and considerations

angioedema, cv effects, retention

pyridostigmine (mestinon) type

cholinesterase inhibitor

pyridostigmine (mestinon) indications

myasthenia graves

pyridostigmine (mestinon) effects and considerations

SLUDGE, BBB

pyridostigmine (mestinon) moa

increases available ACh

memantine (namenda) type

inhibits NMDA

memantine (namenda) moa

blocks calcium entry

memantine (namenda) indications

AD

memantine (namenda) effects and considerations

dizziness, head ache, hallucinations

levodopa/carbodopa (sinemet) receptor

dopamine

levodopa/carbodopa (sinemet) moa

increases dopamine that can’t cross BBB

levodopa/carbodopa (sinemet) indications

Parkinsons

levodopa/carbodopa (sinemet) effects and considerations

n/v, ticks, b1 effects

take 2 years to take effect, only lasts for 5 years, not curative

rocuronium receptor

nicotinic m

rocuronium moa

blocks Ach causing muscles to relax

rocuronium indicaitons

intubation durration 1 hr

rocuronium effects and considerations

resp. arrest, hypotension

admin with anesthesia

succinylcholine (anectine) receptor

nicotinic m

succinylcholine (anectine) moa

constant depole

succinylcholine (anectine) indications

intubation duration 4-10 mins

succinylcholine (anectine) effects and considerations

hyperthermia, hyperkalemia

lidocaine (xylocain) moa

blockas Na

lidocaine (xylocain) indicaitons

anesthetic

lidocaine (xylocain) effects and considerations

CNS depression

asprirate, put pt on telemetry

nitrous oxide moa

increases analgesic

nitrous oxide indications

anesthetic

nitrous oxide effects and considerations

n/v, respiratory distress

midazolam (versed) moa

promotes GABA (inhibitory)

midazolam (versed) indicaitons

anesthetic

midazolam (versed) effects and considerations

respiratory depression, hypotension, cardiac arrest

use with fent

propofol (diprivan) moa

promotes GABA (inhibitory)

propofol (diprivan) indications

anestheticpropofol (diprivan)

propofol (diprivan) effects and considerations

respirator distress, hypotension, infection

ketamine (Ketalar) moa

dissociative anesthetic

ketamine (Ketalar) effects an considerations

resp. distress, hallucinations, abuse