Anti-Cancer Indications

Cytosine arabinoside (ara-C, cytarabine)

AML

Methotrexate

1. Solid epithelial (breast, bladder, head, neck)

2. Osteosarcomas and hematologic tumors

3. RA and psoriasis

5-fluorouracil

Solid tumors (breast, skin, advanced colorectal)

6-mercaptopurine and 6-thioguanine

ALL

2-chlorodeoxyadenosine

1. Hairy cell leukemia

2. Lymphoma

2-deoxycoforomycin

1. T-cell lymphoma

2. Hairy cell leukemia

Gemcitabine

Pancreatic cancer

Mechlorethamine

1. Lymphoma

2. Bladder

Cyclophosphamide

1. Solid tumors

2. Hematologic tumors

Nitrosoureas

1. Brain tumors

2. Lymphomas

3. Myeloma

Platinum Compounds

Drug refractory solid tumors (testicular, ovarian)

Dacarbazine

1. Metastatic melanoma

2. Hodgkin’s Lymphoma

Procarbazine

1. Hodgkin’s lymphoma

2. Glioma

Temozolomide

1. Gliomas

2. Melanoma

Doxorubicin

Solid tumors

Daunorubicin

1. AML

2. Liquid tumors

Etoposide

1. Small cell lung cancer

2. Testicular cancer

Teniposide

1. ALL

2. Neuroblastoma

Bleomycin

1. Solid tumors (testicular cancer, head, neck, skin)

2. Lymphomas

Vinblastine / Vincristine

1. Hematologic tumors (lymphoma)

2. Solid tumors (testicular, breast, lung)

Paclitaxel

Solid tumors (ovarian, breast, non-small cell lung cancer)

L-asparaginase

1. ALL

2. Lymphoma

3. Mast cell tumors

5’aza 2’ deoxycytidine

Myleodysplastic syndrome (pre-leukemia)

All trans retinoic acid (ATRA)

Acute Promyelocytic Leukemia (AML)

Histone Deacetylase Inhibitors (SAHA, vorinostat)

Cutaneous T-cell lymphoma

Glucocorticoids

1. Lymphomas, mutliple myeloma, lymphocytic leuekmia (ALL and CLL)

2. Brain tumors or metastases

3. Blocks cortical pathways of emesis

4. Treatment of hypercalcemia with malignancy

Progestins

1. Endometrial carcinoma

2. Breast cancer

3. Renal cell carcinoma

Leuprolide (GnRH)

Prostate cancer

SERMs (tamoxifen)

1. ER + breast cancer

Selective aromatase inhibitors (letrazole)

ER + breast cancer in the post-menopausal setting

Interferon alpha

1. Hairy cell leukemia

2. CML

3. Melanoma

4. AIDS-related Kaposi’s sarcoma

Interleukin-2

1. Metastatic renal cancer

2. Metastatic melanoma

STI571 (Gleevec)

1. CML

2. Gastrointestinal stromal tumors (GIST)

PLX4032 (Vemurafenib)

1. Metastatic melanoma

2. Thyroid cancer

Herceptin

1. HER2+ breast cancer

Nivolumab

1. Melanoma

2. Renal cell carcinoma

3. Non-small cell lung cancer