allosteric regulation of enzymatic activity

Glucokinase (liver)- activate

NONE

Glucokinase (liver)- inhibit

fructose-6-phosphate

Hexokinase (muscle)- activate

NONE

Hexokinase (muscle)- inhibit

Glucose-6-phosphate

Phosphofructokinase-1 (liver): activate

AMP

Phosphofructokinase-1 (liver): inhibit

Citrate, ATP, low PH

Phosphofructokinase-2, phosphatase activity (liver): activate

NONE

Phosphofructokinase-2, phosphatase activity (liver): inhibits

Fructose-6-phosphate

Phosphofructokinase-2, kinase activity (liver): activate

inorganic phosphate

Phosphofructokinase-2, kinase activity (liver): inhibits

Citrate

Phosphofructokinase (muscle): activate

AMP

Phosphofructokinase (muscle): inhibits

ATP, low PH

Pyruvate Kinase (muscle): activate

Fructose-1,6-bisphosphate

Pyruvate Kinase (muscle): inhibits

ATP

Pyruvate dehydrogenase (phosphatase): activate

Ca²⁺

Pyruvate dehydrogenase (phosphatase): inhibits

NONE

Pyruvate dehydrogenase (kinase): activate

ATP, Acetyl CoA, NADH

Pyruvate dehydrogenase (kinase): inhibits

Pyruvate, ADP

E2: activate

Coenzyme A

E2: inhibit

Acetyl CoA

E3: activate

NAD+

E3: inhibits

NADH

Citrate Synthase: activate

NONE

Citrate Synthase: inhibits

ATP

alpha-ketoglutarate dehydrogenase: activate

NONE

alpha-ketoglutarate dehydrogenase: inhibits

ATP, Succinyl A, NADH