immunology final questions

dr park :((((((

What is the role of HLA-Cw6 in psoriasis pathogenesis?

b) presenting self-peptides to CD8+ T cells

HLA-Cw6 positive psoriasis patients are more likely to:

b) have early-onset, severe, plaque/guttate disease

MHC class I molecules primarily present which type of peptides?

b) endogenous peptides to CD8+ T cells

MHC I vs II

MHC I:

• all nucleated cells

• endogenous peptides

• CD8+ cytotoxic T cells

• proteasome loaded into ER

• monitoring for intracellular infection and cancer

MHC II:

• APCs (antigen-presenting cells)

• endogenous peptides

• CD4+ helper T cells

• activate helper T cells

Which of the following features is more typical of psoriatic arthritis than rheumatoid arthritis?

c) involvement of enthesitis

A 35-year-old man presents with diffuse swelling of his right index finger (“sausage digit”) and nail pitting. He has a history of psoriasis. Which feature best distinguishes psoriatic arthritis from rheumatoid arthritis? 

c) dactylitis and DIP involvement

A 38-year-old woman with chronic plaque psoriasis develops joint pain. She is HLA-Cw6 positive. Which autoantigen is most often presented to CD8+ T cells in her disease?

b) LL-37

What is the most important pathological consequence of activated neutrophils in Lupus?

b) release of nuclear antigens that stimulate DCs

Why the other answers were wrong:

What is the most important pathological consequence of activated neutrophils in Lupus?

• a) increases antigen presentation via MHC I → increases antigen presentation via MHC II

• c) enhanced phagocytosis of apoptotic cells → decreased phagocytosis of apoptotic cells

• d) production of IL-17 → this is in PsA

• e) decrease in type I interferon levels → increase in type I interferon levels

In lupus, monocytes/macrophages contribute to chronic inflammation primarily by:

b) producing pro-inflammatory cytokines like IL-6 and TNF-ɑ

What finding is the earliest innate immune abnormality that sets the stage for lupus pathogenesis?

b) defective clearance of apoptotic cells

Defective clearance of apoptotic cells in lupus mainly promotes autoimmunity by:

b) presenting self-antigens to autoreactive lymphocytes

In lupus, a reduction in regulatory T cell (Treg) activity leads to:

b) suppression of Tfh cell activity

What is the primary immune pathway involved in acute gout inflammation?

b) NLRP3 inflammasome activation in innate immune cells

Which immune system arm plays the dominant role in acute gout?

b) innate immunity

Which adaptive immune cell type is most often found in chronic gout lesions?

a) Th17 CD4+ T cells