carbon dioxide transport

Co2 in blood

carried mostly in the form of HCO3 bicarbonate

-other forms include 

• H2CO3

• carbaminohemaglobin 

carbon dioxide transport

co2 waste product from aerobic cellular respiaration moving to skeletal muscle/tissue→ systemic capillaries → RBC → Plasma

co2 in the systemic capillaries

reacts with water in the RBC of the systemic capillaries and plasma

carbonic anhydrase

bicarbonate enzyme that catalyzes H20+CO2→ H2CO3

H2CO3

a weak acid that disassociates into HCO3 & H+

-catalyzed by carbonic anhydrase

chloride shift

involves transport of co2 (HCO3) into plasma and movement of CI- into RBC

Band 3

anti-port that diffuses HCO3 (co2) out of RBC into plasma

and moves CI- in against (the concentration gradient) into RBC from plasma 

why does Band 3 move RBC out

to ensure that reaction proceeds to the right

making sure that the reaction proceeds to the right

band 3 continues it to the right to dissociate the carbon and h2o

H2O + CO2 → H2CO3 → H_⁺ + HCO3

*cycle*

why does Band 3 move CI- into RBC

to maintain electrical neutrality of RBC

-CI- replaces the negative charge loss due to HCO3 leaving

co2 from tissue will..

-will dissolve in plasma (10%)

-coming with hemoglobin to form a carbaminohemoglobin

-or will facilitate in the bohr effect which leads to the unloading of o2 from a oxyhemoglobin