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vaccine material
antigens that subsitute fo the pahtogens that would cause disease
killed bacteria or inactivated virus...
cannot cause infection
attenutated bacteria or viruses
attenuated means alive but "weakened"(credit to Pasteur) cannot acuse cause disease but are immunogenic(cause immune system to produce antibodies)
accellar/antigenic fragments
antigens from cells or viruses
toxoid
inactivated toxin but still antigenic
purified polysaccharide
polysaccharide conjugated with protein
(protein strengthens immune response)
principle vaccines used in the U.S. to present bacterial diseases in humans...↓
DTap
Diptheria
purified diptheria toxoid
pertussis
acellular fragments of purified from Bordetella pertussis(~12Ag) kills babies
tetanus
purified tetanus toxoid
meningococcal meningitis
purified polysaccharide from N. meningitidis
Haemophilus influenza type b meningitis (HiB vaccine) is made of...
polysaccharides conjugated with proteins
Pneumococcal conjugate vaccine :
Streptococcus pneumoniae antigens conjugated
Measles vaccine is...
attenuated virus
what is the MMR vaccine for
Measles mumps and rubella
mumps vaccine is...
attenuated virus
rubella vaccine is...
attenuated virus
chicken pox vaccine is...
attenuated virus(shingles----Herpes zoster = same)
human papilloma virus(HPV) vaccine is...
Ag fragments
human papilloma virus(HPV) vaccine prevents
cancers later in life
hepatitis A
inactivated virus
hepatitis B
antigenic fragments(recombinant vaccine)
poliomyelitis vaccine is...
inactivated virus(Salk vaccine)(Sabin is attenuated virus vaccine another version but not as safe)
SARS----CoV----2 vaccine is a...
RNA vaccine
how many vaccinations and boosters are recommended in the first year of life?
22 vaccinations or boosters
passive immunization
someones else's preformed anitbodies, protiecion developing your onw antidbodies
how to people with antibodies give it to other people?
take their blood through titers, gamma globulin (antibodies from a pooled serum) and give to others.
advantages of passive immunization
protections from immunocompromised(who can't get vaccines)
immediate protecion
temporary protection while immunity develops
what are some disadvantages of passive immunization?
serum sickness (animal preperations)
no lasting immunity
Immunoglobulin g (ImG)
get from your mother
naturally acquired active immunity
disease or Normal exposure(antibody)
naturally acquired passive immunity
placenta/breast milk(mother to child)
artificially acquired active immunity
vaccines
artificially acquired passive immunity
gamma globulin injection(get antibodies from someone else who already created it in blood)
immunological disorders
response to antigens(allergens) that leads to damage
what are the types of reactions?(4 of them)↓
i. anaphylactic
ii. cytotoxic
iii. immune complex
iv. cell mediated (or delayed type)
type i. anaphylaxis
first exposure to sensitizing antigen causes B cells, with help of TH cells to make IgE, IgE(receptor and ability to bind to mast and basophils), IgE binds to mast cells(or basophils) at the antibodies constant region, on later exposure antigen bind to IgE at the antigen----binding site, stimulating the mast cell to degranulate, release of inflammatory mediator, including histamines prostaglandins and leukotrienes, that cause an allergic response.
type i. anaphylaxis
allergy development(immunization----sensitized to allergen produces IgE antibody
cellular response (IgE binds to Fc receptor---- mast cells basophils)
antigen binds IgE
cross----linking of IgE antibodies
degranulation---- release of chemical mediators, histamine, prostaglandins, leukotrienes
symptoms ---- smooth muscle contraction(bronchia) vascular permeability, swelling edema, respiratory distress, death
type ii. Cytotoxic Reactions
cytotoxic reactions involve IgG or IgM antibodies and complement activation
cell lysis or damage by macrophages
hemolytic disease of a newborn Rh factors "blue baby"
Rh+ father
Rh---- mother carrying Rh+ fetus, Rh antigens from the developing fetus can enter the mothers blood during delivery
in response to the fetal Rh antigens the other will produce antibodies that are anti----Rh antibodies
if the woman becomes pregnant with another Rh+ fetus, her anti----Rh antibodies will cross the placenta and damage the fetal RBC
what type of Ig affects the baby's blood?
iii. immune complex----mediated hypersensitivity
systemic lupus erythematosus (SLE)
antibodies to cell nucleus components
deposits in many areas
kidneys‒ most common
skin‒ causes butterfly rash on face(lupus wolf)
joints‒arthritis
brain‒mental
rheumatoid arthritis
antibodies to rheumatoid factor
chronic joint inflammation/damage
type iii. immune complex-mediated hypersensitivity
immune complexes are deposited in wall of blood vessel
presense of immune complexes activates complement and attracts inflammatory cell such as neutrophils
enzymes released from neutrophils cause damage to endothelial cells of basement membrane
type iv. cell----mediated
t cell response - delayed(12-48 hrs after exposure) not antibody mediated
first exposure- t cells sensitized, cell proliferate ‒ T clone increases
second exposure ‒ t cells activated by antigen, release lymphokines, stimulate macrophages and inflammatory response(symptoms)
resin of poison ivy and skin protein reaction
body recognizes non----self and t cell come and attack skin proteins(dermatitis)
Mantoux tuberculin skin test involves...
purified protein derivative(antigen) extracted from Tb cell
PPD intradermally
a previous infection or exposure to Tb= sensitivity to Td cells
a positive reaction is Type IV hypersensitivity, once positive always positive if you want to check for infection use chest x-ray, this test is for IMMUNITY.
how to check for active infection of Tb?
use chest x----ray to check for active infection
The mRNA molecules used in the Moderna (Mod) and the Pfizer----BioNTech (P----Tech) vaccines contain genetic information for what SARS----CoV----2 viral component?
spike protein
How is the fragile mRNA molecule in the vaccines physically protected from destruction (in the vials and after the IM injection)?
a lipid----based nanoparticle surrounds the mRNA
How is the mRNA in the Johnson and Johnson vaccine protected?
it's inside a harmless cold virus protein shell (aka, the capsid ---- remenber that term?)
After injection into the body, all 3 vaccines stimulate the activity of what type of immune cells to create immunity?
Antigen processing cells (APC)
Helper T-cells
B-cells
Cytotoxic T-cells
What "type" of hypersensitivity is the human reaction to poison ivy?
Type IV
What component of poison ivy causes the itchy skin reaction?
An allergen in the sap called urushiol
What "chemical mediator" is released during the reaction to poison ivy, and where is the chemical active?
IL----33, the skin's nerve cells
In the research trials, how was the itch response diminished or eliminated in the test mice?
Antibodies against the active chemical mediator and antibodies against the nerve receptors prevented the itch
Approximately how many vaccines and antiviral treatments are currently in development to reduce hospitalizations due to the SARS----CoV2 virus?
more than 80
If antibiotics are known not to be effective against virus infections why would there be a need to use antibiotics with this virus?
Many COVID infections can lead to secondary bacterial pneumonia, requiring effective antibiotic treatment
Why are hospitals discouraged from using new antibiotics from treating antibiotic resistant infections associated with serious COVID infections?
The hospitals don't get reimbursed for using the sometimes very expensive new antibiotics
How does author propose to help hospitals use the most effective antibiotic available to treat patients with bacterial pneumonia?
Allow reimbursement for the use of the most effective antibiotic, and provide incentives for new antibiotic research and development
T/F : Cases of scarlet fever have been rising in many countries around the globe.
true
The causative agent of Scarlet Fever is
Streptococcus pyogenes
The causative agent of Scarlet fever can also cause
Impetogo
Strep throat
pneumonia
flesh-eating disease
The cause of Scarlet fever is most often spread by
Saliva droplets released by coughing and sneezing
Serious complications that can arise due to Scarlet fever infection include
Rheumatic fever
Scarlet fever is successfully treated with
antibiotics
The 3 viruses in the "tripledemic" are
respiratory syncytial virus
Influenzavirus
SARS-CoV-2
The ILI epidemiology data show that outpatient visits for respiratory illness in the Fall of 2022...
show a much earlier increase than most of the past 5 years.
How does the flu season in 2020----21 compare to nearly all the other recent flu seasons?
Nearly non----existent, hardly any flu symptom visits to Doctors' offices.
These tripledemic viruses increase the risk for co----infection. What is meant by "co----infection"?
An individual can be infected with 2 or more of these viruses.
This Salmonella outbreak is linked to Honey Smacks cereal. The cereal would be considered as the...
Vehicle
The outbreak due to eating the cereal consisted of
73 cases, 24 hospitalizations, no deaths
The FDA recommends this if you have purchased Honey Smacks
Do not eat any of the cereal and discard any leftover cereal, or return it to the store.
Symptoms of Salmonella infection would include...
Vomiting, diarrhea, fever
How did the Salmonella most likely get into the cereal manufacturing plant?
From Salmonella contaminated ingredients or from an ill worker
Compared to several years ago the incidence of Salmonella and E. coli infections today is
lower than past years.
According to the CDC how does the incidence of E.coli food borne illness compare to the Salmonella illness rate?
Much higher rate for Salmonella
T/F : The recent case of polio in NY involved a person who was previously vaccinated against the poliovirus.
false
What danger did this individual case have for the general population in his area?
No danger for fully vaccinated children and adults ---- getting the recommended doses of polio vaccine is highly protective.
Globally, the recent trend in vaccination rates for various diseases has been...
---- going down for several serious diseases, including polio and measles
T/F : Vaccine hesitancy, i.e. not getting recommended vaccinations, can affect overall public health. Since this mainly concerns COVID vaccines, routine childhood vaccinations have not been influenced by anti----vaxxers.
false
Polio, originating and spreading in the US population, was eliminated in the US because of its high vaccination acceptance. What year was polio considered eradicated in the US?
1979
How is the poliovirus most commonly transmitted?
Fecal----oral ---- usually contaminated food or water.
antibiotics are made of…
plants+microbes
the "Magic Bullet" concept...
bullet kills only selected pathogen and not the innocent bystander(host cells)
Paul Ehrilich
#606 cured Trypanosomal infection in mice(test) then use on syphilis patient(worked on most but killed other)
the magic bullet was developed by
Paul Ehrlich in early 1900's a Germán organic chemist tested 100s of organic arsenic cmpds
modern term for "magic bullet"
selective toxicity
theraputic index is
the max dose that is not toxic to patient divided by min effective dose against pathogen
therapeutic index example equation 10mg/kg effective does is 2m/kg therapeutic index is...
TI=5
narrow spectrum of microbial activity
drugs that affect a narrow rang of microbial types
broad----spectrum antibiotics
affect a broad range of Gram----positive and Gram----negative bacteria
superinfection
overgrowth of normal microbiota that is resistant to antibiotics
in 1928 Fleming discovered
penicillin produced by Penicillium(a mold)
1940 Howard Florey and Ernst Chain performed
first clinical trials of penicillium extracted and turned into medicine
when penicillin is around the bacterial cell...
lyses because the penicillin weakens the cell wall and the cell explodes
what bacteria is resistant to penicillin?
Staphylococcus aureus
Major actions modes of antibacterial drugs(list 5)
inhibition of cell wall synthesis(penicillin, cephalosporins bacitracin, vancomycin)
inhibition of proteins synthesis( chloramphenicol, erythromycin, tetracyclines, streptomycin)
inhibition of nucleic acid replication and transcription : quinolones, rifampin
injury to plasma membranes: polymyxin B
inhibition of essential metabolite synthesis(sulfanilamide, trimethoprim)
the original antibiotic prescription for a bacterial infection "stopped working" and you are prescribed a new one. Explain why the first one didn't work?
the bacteria developed resistance to the antibiotic and was no longer susceptible
(not counting antibiotic allergies) Can a person ever become "immune" to an antibiotic so that it no longer works?
no, the bacteria that becomes genetically or metabolically resistant to the antibiotic NOT YOU
antibiotic resistance mechanisms(list 3)
resistance genes
cell mutation event
multiple resistance