Oxford Text pg 306-312

tricyclic antidepressants (TCA’s)

depression-relieving drug with three rings of atoms

MAO (monoamine oxidase) inhibitors

well-known class of antidepressants which inhibits monoamine oxidase

SSRI’s

most widely used class of antidepressants

treatment of adolescents with depressions - study ( TADS)

multi-site clinical research study founded by the NOMH, found all three active treatments outperform placebo

chemical imbalance theory

proposition that depressive symptoms are caused by neurotransmitter imbalances in the brain

Kinsch (2014)

said the effectiveness of antidepressants can be attributed to the placebo effect

Kirsch (2002)

replicated the meta-analysis, found 82% of the effect of antidepressants was duplicated by placebo

statistically significant

reliably different from zero

Hollow et al (2002)

argued most research studies in this area included patients who were not severely depressed

Elkin et al (1989)

patients were assigned to one of four 16-week treatment conditions, found drugs to be separate to placebo

Bockting et al (2008)

found 68% of patients who initially met remission criteria and continued meds relapsed in the range of 2 years