Krebs Cycle steps

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Last updated 10:03 PM on 11/20/25
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8 Terms

1
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step 1

condensation of acetyl-CoA and oxaloacetate to form citrate via citrate synthase

2
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step 2

isomerization of citrate to isocitrate via aconitase

3
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step 3

formation of alpha ketoglutaride and release of co2 and nadh via isocitrate dehydrogenase

4
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step 4

formation of succinyl-CoA from alpha ketoglutarate via alpha ketoglutarate dehydrogenase

5
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step 5

hydrolysis of the thioester bond of succinyl-CoA and the fomration of succinate and GTP via succinyl-CoA synthetase

6
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step 6

oxidation of succinate to fumarate and the release of FADH2 via succinate dehydrogenase

7
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step 7

trans-hydration of the fumarate double bon to form L-malate via fumarase

8
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step 8

oxidation of L-malate to oxaloacetate which completes the TCA cycle via malate dehydrogenase