Phagocytes

Neutrophils

General purpose

First line of defense to bacteria & foreign materials

Damages tissues

Eosinophils

Attracted to sites of parasitic infections and antigen-antibody reactions

Macrophages

Derived from monocytes

Scavenge and process foreign substances to prepare them for reactions with B and T lymphocytes

Pattern Recognition Receptors (PRRs)

Found on pathogen

Pathogen Associated Molecular Patterns (PAMPs)

Found in cell membrane of host macrophages

Made of proteins

Signals the macrophage to produce cytokines

Toll-Like Receptors (TLR) attach to these

General Activities of Phagocytes

Survey tissue compartments, ingest & eliminate materials, & extract immunogenic information from foreign matter