Amino Acids/ Properties

Non-polar (hydrophobic) amino acids

L, A, V, I, W, F, M, P, G

Polar Amino Acids + Uncharged @pH 7.0 + Hydrophilic

• C pka = 8.4 (mostly protonated at pH 7.0)

• Y pka = 10.5 (mostly protonated at pH 7.0)

N, Q, T, S, C, Y

Positively charged (basic) amino acids + Polar + Hydrophilic

K, R, H

Negatively charged (acidic) amino acids + Hydrophilic + Polar

• Mostly deprotonated at pH 7.0

• Asp, D pKa 3.9

• Glu, E pKa, 4.1

D, E

Phenylalanine

Phe, F
Hydrophobic, Non-polar

Valine

Val, V
Hydrophobic, Non-polar

Isoleucine

Ile, I
Hydrophobic, Non-polar

Leucine

Leu, L
Hydrophobic, Non-Polar

Proline

Pro, P
Hydrophobic, Non-Polar

Alanine

Ala, A
Hydrophobic, Non-Polar

Glycine

Gly, G
Hydrophobic, Non-Polar

Tyrosine

Tyr, Y
Hydrophobic, Non-Polar

pKa 10.5

Cysteine

Cys, C
Hydrophobic, Non-Polar

pKa 8.4

Methionine

Met, M
Hydrophobic, Non-Polar

Aspartic Acid

Asp, D
Acidic -

pKa 3.9

Glutamic Acid

Glu, E
Acidic -

pKa 4.1

Arginine

Arg, R
Basic +

pKa 12.5

Lysine

Lys, K
Basic +

pKa 10.5

Threonine

Thr, T
Hydrophilic, Polar

Asparagine

Asn, N
Hydrophilic, Polar

Glutamine

Gln, Q
Hydrophilic, Polar

Serine

Ser, S
Hydrophilic, Polar

Histidine

His, H
Hydrophilic, Polar, Basic

pKa 6.0

Tryptophan

Trp, W
Hydrophobic, Non-polar