nanoparticles

Nanotechnology is a multi disciplinary science dealing with materials in the….

Nanoscale 10-9

Define nanoparticle

Ultra fine particle with at least one dimension less than 100 nanometers

Nanomaterial

Natural or manufactured material where at least 50% of the particles have one or more dimensions between 1 and 100 nm

Examples of engineered nanoparticles

Intentional manufactured to have specific properties

SPIONS

Dendrimers

Gold

Titanium dioxide

Carbon nano tubules

Spions

Iron oxide - MRI contrast agent, bio comparable with no severe toxic effect

Dendrimers

1. Use

2. Toxicity depends on

Drug carrier, gene delivery systems

Branched molecules

Higher generation more toxic

Cation more toxic

MSNS mesoporous silica particles

Porous, honey comb

Drug carrier

Gold nanoparticles

Cancer therapy

Smaller particles more cytotoxic

Carbon nanotubes

1. Structure

2. Routes

3. Health effects

Hexagonal structure, single or multiple walls, carbon atoms

Skin absorption and lung

Not well recognized by alveolar macrophages

Granuloma and lung fibroses

Titanium dioxide nanoparticles

Pigments, paints, food

Inhalation for occupational

Oral

Safe