Failure of negative selection of T cells

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4 Terms

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What is the goal of negative selection in T cells?

To eliminate T cells that recognize self-antigens before they leave the thymus.

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Why must developing T cells be exposed to tissue-specific proteins?

To prevent them from targeting those proteins in the body later on.

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What role does AIRE play in negative selection?

AIRE helps thymic APCs express tissue-specific proteins to expose developing T cells to a broad range of self-antigens.

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