Dengue

single-stranded positive sense RNA

Genome

humans, mammals, insects

host species

mosquitos

how is dengue transmitted?

hemorrhagic fever, encephalitis

What does dengue cause?

antibodies (E protein)

What does Dengue target?

protease

the genome is one long polyprotein covered up by viral

host RNA

genomic RNA looks like

travellers

spread of the disease in the US is associated with

vectors

circulates in human and primate cycles with different

aedes

human mosquito vector

hemagogues

primate mosquito vectors

primates

Dengue is a spillover from infected

High fever, nausea, vomiting, rash, aches, pains

Dengue disease

shock, internal bleeding, death

for 1/20 people infected with dengue experience

1/2

___ world’s population at risk of infection

390 million

How many annual infections?

mosquito range

global connectivity and climate change have expanded

asymptomatic to severe

dengue ranges from

3/4

__ are asymptomatic

4

Dengue has _ serotypes

antigens

dengue groups are distinguished by shared specific

offers short term protection, but long-term antibody dependance

antibodies from one react w/others

severe disease

secondary dengue infections will have a higher risk of

risk

abberact cytokine secretion causes the ___ of sever disease

to induce longterm protection w/out immune enhancement

What is the goal of the DENV vaccine?

Live attenuated

DENV vaccine is

antigens for all four serotypes

DENV vaccine induces

primary infection

for people who haven’t been infected the vaccine can fight off

Wolbachia

the bacteria being used to infect mosquitoes and reduce dengue transmission