Parasympathetic Effect on Pacemakers/Cardiac Muscle Cells
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10 Terms
Which neurotransmitter mediates parasympathetic effects on pacemaker cells?
Acetylcholine (ACh)
How does ACh affect K⁺ permeability in pacemaker cells?
Increase K+ permeability
What does ACH allow K+ efflux to do?
leaves the pacemaker cells
What is the effect of increased K⁺ efflux on the pacemaker cell membrane?
Hyperpolarization
How does parasympathetic effect affect Na⁺ and Ca²⁺ inward currents in pacemaker cells?
Limits both/inward currents
What is the outcome of parasympathetic effect on pacemaker cells
Less frequent APs at the SA node (Heartbeat decreased)
Which part of the heart is primarily affected by parasympathetic stimulation in cardiac muscle cells?
Atrial cardiomyocytes
Atrial Cadiomyocytes
reduction in the slow, inward current of Ca2+ during plateau phase (atrial contraction weakened)
Which channels are inhibited or slowed by ACh in atrial cardiomyocytes in cardiac muscle cells?
L-Ca2+ channels
What is the consequence of decreased Ca²⁺ influx during each contraction?
Less CBs & Force production
