skeletal system

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43 Terms

1
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What happens in the body when someone has Fibrodysplasia Ossificans Progressiva (FOP)?

muscles and connective tissue turn into bone

2
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what are the functions of the skeletal system?

support, protection, body movement, blood cells formation, storage of inorganic materials

3
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what is the term for blood cell formation? where does it happen?

hematopoiesis - red bone marrow

4
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which inorganic materials does the skeletal system store?

calcium, magnesium, sodium, and potassium

5
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About how many bones are in the skeletal system?

206

6
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What are the two divisions of the bones?

axial and appendicular

7
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what makes up the axial division?

head, trunk, neck, skull, hyoid bone, vertebral column, ribcage, sternum (think the inner/upper section of the body)

8
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what makes up the appendicular division?

pectoral girdle (collarbone and shoulder area), arms, pelvic girdle, legs (think the “exterior” part of the body)

9
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what causes flare-ups of bone growth with FOP?

any slight injury or minor trauma

10
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will FOP result in death?

yes, eventually it will because muscles are important for function

11
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what are the ends of bones called?

epiphysis

12
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what is the main region/shaft of the bone called (the part in between the epiphysises)?

diaphysis

13
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what is the cartilage covering the ends of the bones?

articular cartilage

14
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what is the tough membrane covering the entire bone?

periosteum

15
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what is within the diaphysis and contains bone marrow?

medulla/medullary cavity

16
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what does proximal epiphysis mean?

closest to the body’s center

17
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what does distal epiphysis mean?

farthest away from the body’s center

18
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what are the types of bones and their functions?

flat - protection

long - support weight and movement

short - stability/movement

irregular - protects organs

sesamoid - reinforces tendons

19
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what is the lining of the medullary cavity called?

endosteum

20
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what does red marrow do?

produce blood cells

21
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what does yellow marrow do?

store fat

22
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where is compact bone found in the bone?

the wall of the diaphysis

23
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where is spongy/cancellous bone found?

the epiphysis

24
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what is bone tissue called? what is its matrix composed of?

osseous tissue - collagen and inorganic salts

25
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what is collagen?

connective, supportive tissue

26
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what are mature bone cells called?

osteocytes

27
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what are the tiny chambers that osteocytes are enclosed in called?

lucanae

28
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what are the rings formed by the lucanae called? what do they form around?

lamallae - haversian canal

29
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what connect osteocytes?

canaliculi

30
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are Volkmann’s canals horizontal or vertical?

horizontal

31
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are haversian canals horizontal or vertical?

vertical

32
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what is ossification?

the process by which hyaline cartilage (which is what bones initially are) gradually changes into bone tissue

33
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what does the primary ossification center do?

increase diameter

34
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what does the secondary ossification center do?

increase length

35
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what is hallux adbucto calgus deviation?

when the toes are bent due to abnormal ossification

36
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what did jasmin’s mother notice that led to a FOP diagnosis?

ossification in the toes (bent shape) and stiff neck

37
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what do osteoblasts do?

create osteocytes

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what do osteoclasts do?

absorb or consume osteocytes

39
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what is the epiphyseal disk/line (growth plate) and how does it change with age?

a band of cartilage between the epiphysis and diaphysis - slowly “closes” or goes away with age (bigger growth plate at young age, meaning there is more room to grow)

40
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what is heterotopic ossification (HO)?

abnormal bone growth in non-skeletal tissues including muscle, tendons, and soft tissue

41
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what is the cause of FOP?

gene mutation that codes for more bone morphogenetic protein (BMP) than usual; the receptor stays ON all of the time

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what are noggin and gremlin?

inhibitors of BMP

43
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what can be done for ppl with FOP?

CRISPR- get rid of the mutation and replace it with the normal gene