Hematology Exam #2

Sodium metabisulfite

________- Mixing blood with the reducing agent ______ _________ induces sickling in susceptible cells in the Sickle Solubility test.

Osmotic fragility

What is decreased if there is a shift of the curve to the [left /right]

Howell

________- jolly body- A type of inclusion body containing DNA.

Hemolysis

________- As long as haptoglobin is not bound to hemoglobin, that means there is no ________.

Serum enzymes

________: increasing as disease advances.

__x__

________ is the substrate for the enzyme ___________ ________, which takes a methyl group from ____________ and conjugates it to ________, forming ____.

RBCs

________: variable (normo, micro,)

Marrow

________ is ______ with primarily __________ and ______ cells.

___

THF, homocysteine, methionine, 5- methyl- THF, serine hydroxymethyl transferase, methylene- THF- 2. ________ is generated by ____________ converting to __________ and transferring methyl group and sourced form ____________.

Hemoglobin H

________ is detectable in blood; precipitates and damages RBCs, causing _____________ _________.

Sickle cell trait

________ (Hgb AS)- Clinically normal presentation; acute vasoocclusion occurs only under extreme conditions (vigorous exertion at high altitude)

TIBC

Hereditary hemochromatosis- autosomal recessive blood disorder; one of the most common inherited diseases. Hemochromatosis- Serum Fe: increased. ________: normal or increased.

Serum ferritin

________- directly proportional to the amount of Fe stored.

Sideroblastic anemia

Acquired seconary- ________ that can be caused by chronic alcoholism, lead toxicity, certain medications; e.g., chloramphenicl. ________- Serum Fe: increased.