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Chemotaxis
release of bacterial byproducts attract phagocytes which extend pseudopods to catch the pathogen
Adhesion
pseudopods attach to PAMP
Ingestion
pseudopods retract and uptake pathogen; plasma membrane surrounds pathogen in an internalized vacuole is called a phagosome
Maturation
phagosome matures while trafficking through the cell and fuses with lysosomes into a phagolysosome
Lysis
lysosomes kill the pathogen with degradative enzymes including lysozyme, hydrolases, reactive oxygen metabolites (H2O2), nitric oxide, and superoxide anions
Elimination
phagolysosome fuses with the plasma membrane, releases debris and displays pathogens’ feature on their surface (important for activation of the adaptive immune system)
Phagocytosis
capturing, engulfing and digesting of foreign particles by phagocytes (e.g. macrophage, dendritic cells, neutrophil)