Hyperlipidemia & cholesterol meds

what is an example of a HMG-CoA reductase inhibitor

statins

what do statins do

• stabilize plaques

• prevent plaque from cracking

• lower LDL

what is a risk with statins

myopathy and liver toxicity

when are statins contraindicated

liver disease, pregnancy, heavy alcohol use

what are examples of PCSK9 inhibitors

mabs

what do PCSK 9 inhibitors do

lower LDLs by 50-60%

when are PCSK 9 inhibitors given?

after statins when LDLs are still too high

why do we like PCSK 9 inhibitors

don’t have many side effects, good if you have heart disease

why do we not like PCSK 9 inhibitors

very spendy

what is an example of a cholesterol absorption inhibitors

Ezetimibe

what are nursing considerations r/t ezetimibe

can be very hard on the liver

how is ezetimibe taken

with statins

what does ezetimibe do

reduce LDL by 18-25%

what is the biggest effect of Niacin

increase HDL and decrease LDL

what is a side effect of Niacin

flushing

what is an example of a fibrate

Gemfibrozil

what med is best a lowering triglycerides

gemfibrozil

what needs to be monitored in pts taking gemfibrozil

liver and kidney function

what cant be combined with fibrates

statins

what can happen if fibrates and statins are used together

rhabdomyolysis 

what is an example of a bile acid sequestrants

cholestyramine

what are side effects of bile acid sequestrants

gut issues, bowel obstruction, constipation

what is bad about bile acid sequestrants

can worsen triglycerides