CellCycleRegulation

Phase of the cell cycle during which cyclin B increases in concentration.

G2

Division of tetraploid post-mitotic “mother” cell into two “daughter” cells.

Cytokinesis

Substrate recognition subunit required in MPF.

Cyclin B

Kinase subunit of both Start kinase and MPF.

CDK2

CyclinB/cdk2 dimer.

MPF

Initial phase of cell growth required to make a cell growth large enough to be divided after mitosis.

G1

Increased _______ is the mechanism for increasing levels of cyclins.

Transcription

Phase of the cell cycle in which replication of most of the genome (DNA) occurs (but not at “centromeres”).

S phase

Substrate recognition protein subunit of Start kinase.

Cyclin A

Substrate recognition subunit required to guide cdk2’s activation of “origin recognition complex” assembly.

Cyclin E

Performs the required phosphorylation of cdk2 for progression into S phase and M phase.

MAPK

Extracellular protein ligand that stimulates cell prliferation.

Growth factor

Phase of the cell cycle in which duplicated chromosomes are separated to the spindle poles.

M phase

Reduces the level of cyclin A during S phase and cyclin B during M phase.

Proteolysis

Required to cross the threshold into S phase.

Start kinase

Growth factor receptors dimerize to form an enzymatic ________ when bound by their GFs.

Tyrosine kinase