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Physical half-life (T1/2)
Is an intrinsic characteristic of each radionuclides
0.693
T ½ is given by the expression of
Physiologic processes
Most radiopharmaceuticals are also cleared from organs by various
Exponential
Biologic clearance of material (radioactivity) from the body can be modeled as being
Sweating and stool
Excretion examples
Biologic half-life (Tb)
The biologic clearance will be characterized by a
Effective half-life (Te)
Encompasess both radioactive decay and biologic clearance
Effective half-lives
Must always be shorter than the physical or biologic half-life
1/Te=1/Tb+1/T1/2
The relation between T1/2, Tb and Te is