Advanced Cardiology Top 300: Quiz #1

What is the brand for Apixaban?

Eliquis

What is the drug class for Apixaban?

Factor Xa inhibitor

What are the dosage forms for Apixaban?

Tablet

Tablet therapy pack

What are the on-label uses for Apixaban?

- Nonvalvular atrial fibrillation (stroke prevention)

- DVT/PE treatment and secondary prevention

- DVT prophylaxis after hip or knee replacement surgery

What are the off-label uses for Apixaban?

Heparin-induced thrombocytopenia (HIT) with or without thrombosis

What is the MOA for Apixaban?

Selectively inhibits factor Xa to decrease thrombin generation and thrombus formation

What are the box warnings for Apixaban?

- Premature discontinuation increases risk of thrombotic events

- Increased risk of spinal/epidural hematoma with neuraxial anesthesia or spinal puncture

What are the contraindications for Apixaban?

- Active bleeding

- Hypersensitivity

Is Apixaban safe for pregnancy/lactation?

Pregnancy: potential risk

Lactation: potential toxicity

What are the adverse effects for Apixaban?

Bleeding

What is the brand for Edoxaban?

Savaysa

What is the drug class for Edoxaban?

Factor Xa inhibitor

What are the dosage forms for Edoxaban?

Oral tablet

What are the on-label uses for Edoxaban?

- Nonvalvular atrial fibrillation (stroke prevention)

- Venous thromboembolism (treatment after 5-10 days of parenteral anticoagulant)

What are the off-label uses for Edoxaban?

Prophylaxis of thrombosis after knee arthroplasty

What is the MOA for Edoxaban?

Selectively inhibits factor Xa that decreases thrombin generation and thrombus formation

What are the box warnings for Edoxaban?

- Premature discontinuation increases risk of thrombotic events

- Increased risk of spinal/epidural hematoma with neuraxial anesthesia or spinal puncture

- Reduced efficacy in nonvalvular atrial fibrillation with CrCl >95 mL/min

What are the contraindications for Edoxaban?

- Active bleeding

- Hypersensitivity

Is Edoxaban safe for pregnancy/lactation?

Pregnancy: Limited human data

Lactation: probably compatible

What are the adverse effects for Edoxaban?

Bleeding

What is the brand for Rivaroxaban?

Xarelto

What is the drug class for Rivaroxaban?

Factor Xa inhibitor

What are the dosage forms for Rivaroxaban?

Oral tablet

Oral tablet therapy pack

Oral suspension

What are the on-label uses for Rivaroxaban?

- Prevention of thromboembolism after orthopedic surgery

- Nonvalvular atrial fibrillation (stroke prevention)

- DVT/PE treatment and secondary prevention

- Coronary artery disease and peripheral artery disease

What are the off-label uses for Rivaroxaban?

Acute coronary syndrome

What is the MOA for Rivaroxaban?

Selectively inhibits factor Xa and blocks conversion of prothrombin to thrombin and prevents clot formation

What are the box warnings for Rivaroxaban?

- Premature discontinuation increases thrombotic risk

- Increased risk of spinal/epidural hematoma with neuraxial anesthesia or spinal puncture

What are the contraindications for Rivaroxaban?

Active bleeding

Is Rivaroxaban safe for pregnancy/lactation?

Pregnancy: moderate risk

Lactation: potential toxicity

What are the adverse effects for Rivaroxaban?

Bleeding, cough

What is the brand for Dabigatran?

Pradaxa

What is the drug class for Dabigatran?

Direct Thrombin Inhibitor

What are the dosage forms for Dabigatran?

Oral capsule

Oral pellets

What are the on-label uses for Dabigatran?

- Nonvalvular atrial fibrillation (stroke prevention)

- DVT/PE treatment and secondary prevention

- DVT/PE prophylaxis after hip replacement

What are the off-label uses for Dabigatran?

- DVT/PE prophylaxis after knee replacement

- Atrial flutter (stroke prevention)

What is the MOA for Dabigatran?

Direct thrombin (factor IIa) inhibitor that prevents conversion of fibrinogen to fibrin and inhibits clot formation

What are the box warnings for Dabigatran?

- Risk of stroke at discontinuation

- Spinal epidural hematoma

What are the contraindications for Dabigatran?

- Active bleeding

- Mechanical prosthetic heart valve

- Hypersensitivity

Is Dabigatran safe for pregnancy/lactation?

Pregnancy: moderate risk

Lactation: potential toxicity

What are the adverse effects for Dabigatran?

Dyspepsia, gastritis, bleeding