Accumulations

Calcium types

Metastatic calcification and dystrophic calcification.

Hypercalcemia

Deposition of calcium within normal or abnormal tissue.

Sarcoidosis

Condition where macrophages activate vitamin D precursor.

Metastatic Calcification

Occurs in patients with hypercalcemia.

Patients who have normal levels of calcium

Have deposition of calcium only within abnormal tissue.

Protein

Accumulations often involve intermediate filament.

Mallory hyaline in the liver

Associated with alcohol.

Hemosiderosis

Accumulation of iron in organs without resultant side effects.

Hemosiderin

A term used for aggregates of ferritin micelles.

Ferritin micelles

Stain positive with a Prussian blue stain.

Hemochromatosis

Accumulation of iron in parenchymal cells resulting in side effects, including congestive heart failure, diabetes mellitus (from damage to the pancreas), and cirrhosis.

Accumulation of fat

Also known as steatosis.

Cholesterol

Accumulates within phagocytic cells in atherosclerosis (veins) or at sites of hemorrhage.

McArdle disease

Results from deficiency or absence of an enzyme called myophosphorylase.

Myophosphorylase

A key substance that muscles need to break down glycogen into sugar.