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Where does the first regulatory checkpoint of gluconeogenesis occur?
In the mitochondria (pyruvate carboxylase converts pyruvate to oxaloacetate)
Where does the second regulatory checkpoint of gluconeogenesis occur?
In the cytoplasm (phosphoenolpyruvate carboxykinase converts oxaloacetate to phosphoenolpyruvate)
Where does the third regulatory checkpoint of gluconeogenesis occur?
In the cytoplasm (fructose 1,6-bisphosphatase converts fructose 1,6-bisphosphate to fructose 6-phosphate)
Where does the dephosphorylation of glucose 6-phosphate occur?
In the endoplasmic reticulum/liver (catalyzed by glucose 6-phosphatase, which is primarily in the liver