Adverse Drug Reactions pt 1 Foreign Language

ADR - expected/ establish

sedation

ADE - isolated access

SJS

ASA + Warfarin

hemorrhage

Alcohol acute

inhibitor

OH chronic

inducer

antidote for Hepatic necrosis associated w/ the overdose acetaminophen

N-acetycysteine

Quinidine

induce Thrombocytopenia

Hydralazine

induce SLE

Primaquine

induce Hemolytic Anemia, due to G6PP deficiency

Chloramphenicol

induce Aplastic Anemia

Oral sulfonylureas

Excessive hypoglycemia

Cardiac glyscoside

Arrhythmia

Albuterol

Tachycardia

AntiHPN

Excessive hypotension

Antibiotics

Diarrhea

CNS Depressants

Sedation

Anticoagulant

Bleeding

Overdosage

results from drug levels above the therapeutic levels

Antihistamine (1st gen)

Sedation insomnia; antianxiety

Menoxidil

(arteriolar vasodilator) for alopecia/ MPB hair growth (hypertrichosis): shampoo (2%)

Opiates (decrease motility)

constipation

Nitroglycerin (vasodilation)

headache

Ace inhibitor (-pril, inh. bradykinin)

cough

Chloramphenicol

Induce Aplastic Anemia

Antipsychotic Agents

Malignant hyperthermia

G6PD + Antimalarials/ Sulfonamides

Hemolytic Anemia

Carbamazepine, Phenytoin, Sulfonamides

Steven-Johnson Syndrome

Herxheimer reaction

(Beta-lactam antibiotic)

Acute intermittent porphyrra (Barbiturates)

Psychosis, Neuropathy, Autonomic Instability

Type I

(Immediate or Anaphylactic Immune Response)

Type II

(Cytotoxic Reactions)

Type III

(Immune Complex Hypersensitivity)

Type IV

(Cell-mediated or Delayed Type)

Type II ex

Hemolytic Anemia (Methyldopa), Aplastic Anemia(Chloramphenicol), Blood Transfusion reactions, Granulocytopenia, Thrombocytopenia

Type III ex

Blood dyscrasias or serum sickness, Arthus Reaction, SLE ( Hydralazine, Phenyotin, INH, Procainamide)

Type IV ex

Tuberculin Skin Test, Contact dermatitis (Poison Ivy)