Pharm FINAL EXAM REV- Urinary/BPH

antimuscarinics & beta-3 agonists

indicated for urge incontinence (bladder sensitivity from infx or neuro disorders)

prolonged QT interval

what is a shared AE of these antimuscarinics?

Darifenacin (Enablex)

Fesoterodine (Toviaz)

Solifenacin succinate (Vesicare)

Tolterodine (Detrol)

Darifenacin (Enablex) & Trospium (Sanctura)

antimuscarinics with the least effect on cognition

Oxybutynin

antimuscarinic which can actually worsen cognitive issues like dementia

empty stomach

how is tropsium taken?

Mirabegron (Myrbetriq)

prescribed as initial therapy or substitute for antimuscarinics;

monitor BP with this beta-3 agonist

local estrogens (Duloxetine)

indicated for stress incontinence

systemic estrogen

can make urinary incontinence worse

Tamsulosin (Flomax)

alpha 1 antagonist, most commonly used med for BPH, given @ night to avoid 1st dose syncope

Alfuzosin

alpha 1 antagonist used for SYMPTOMATIC RELIEF; decreases risk of hypotension

5-alpha reductase inhibitors (finasteride, dutasteride)

women cannot handle these meds (risk to fetus); PREGNANCY

HA & flushing

most common AE of Sildenafil (Viagra)

empty stomach

how must Viagra be taken (otherwise its effects will be delayed)?

Nitrates & alpha blockers

should NEVER be used with Viagra b/c it can cause severe hypotension

Tadalafil (Cialis)

longest duration PDE5 inhibitor

Avanafil (Stendra)

most rapid PDE5 inhibitor

Alprostadil (Muse)

prostaglandin E1 analog which can be given via intracavernosal or intraurethral injection; may cause priapism

serum testosterone

when taking Androgel, Testim, Fortesta (gels) or

Axiron (solution), what must be monitored from 8-10 AM x3 levels?

IM

most reliable administration of TRT replacement