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First Law of Thermodynamics
Energy is neither created nor destroyed, it is transformed from one form to another.
Photosynthesis
CO2+H2O and chlorophyll + sun’s radiant energy → CHO (carbohydrate)
Substrates
Macronutrients that provide energy.
Second Law of Thermodynamics
Transformation of energy is not efficient, heat is a byproduct.
Adenosine Triphosphate (ATP)
The most common high energy, phosphate based chemical compound from which the body derives energy to do cellular work, including muscle contraction.
Adenosine
N2 Base (adenine) + 5-carbon sugar (ribose).
ATP =
Adenosine + P + P ~ P
ATP is stored in the…
Sarcoplasm of the muscle cell.
ATP is like a…
Flare in the trunk of a car, lots of stored energy waiting to be released.
Hydrolysis
The breakdown of ATP to yield energy to perform cellular work.
When an inorganic phosphate molecule (Pi) breaks off from compound…
Energy is released.
Phosphorylation
Resynthesis of ATP by adding a phosphate to ADP left over from hydrolysis.
3 Metabolic Pathways to resynthesize ATP / 3 Energy Systems
ATP/PCr, Gylcolysis, Oxidative
ATP/PCr Energy System
Immediate, phosphagen energy.
Glycolytic Energy System
Anaerobic glycolysis, lactic acid energy system.
Oxidative Energy System
Aerobic energy system.
2 Anaerobic Energy Systems
ATP/PCr + Gylcolytic energy systems) Do not require oxygen to resynthesize ATP, occurs in sarcoplasm of cell.
Anaerobic synthesis of ATP is the primary source of energy for…
Type IIA and IIX muscle fibers, for high intensity, short duration work.
1 Aerobic Energy System
Oxidative energy system. Requires oxygen to resynthesize ATP, occurs in mitochondria.
Aerobic synthesis of ATP is the primary source of energy for…
Type I muscle fibers, for low-moderate intensity, long-duration work.
ATP/PCr energy source
Phosphagens stored in sarcoplasm of muscle cell in form of phosphocreatine (PCr).
PCr
A high-energy phosphagen stored in cells, ready to do immediate work.
Once ATP is hydrolyzed…
PCr helps to rapidly remake ATP.
After hydrolysis we are left with…
ADP + the third phosphate becomes inorganic phosphate (Pi).
To resynthesize ATP…
Need to combine ADP and a phosphate molecule.
By recombining…
Leftover ADP from hydrolysis with PCr stored in cytoplasm → ATP resynthesized.
Creatine kinase (CK)
A rate-limiting enzyme that catalyzes reaction in ATP/PCr energy system.
Once PCr and/or CK is depleted…
Exhaustion of ATP/PCr energy system.
Time to replenish ATP + PCr stores
4-8 minutes depending on how much ATP and PCr were depleted.
Energy source of the Glycolytic Energy System
Glucose (a simple sugar molecule). Muscle either uses blood glucose or glycogen stored in muscle cell to resynthesize ATP.
Glucose
Single molecule of carbohydrates (CHO) after digestion + absorption of CHO.
Glycogen
Long chain of glucose molecules stored in sarcoplasm of the cell.
Time to exhaustion of glycolytic energy system during all-out work
~30-120 seconds.
Glycolysis
Breakdown of glucose molecule from the blood.
Glycogenolysis
Breakdown of glycogen already stored in the cell.
Glyconeogenesis
Making new glucose.
In Anaerobic Glycolysis + Glycogenolysis, glucose is converted to…
Pyruvate (in 10 steps).
Enzyme required for each of the 10 reactions for anaerobic glycolysis + glycogenolysis…
Rate-limiting enzyme PFK.
Anaerobic glycolysis occurs mostly in…
Type IIX and IIA fibers.
Energy sources for Oxidative (Aerobic) Energy System
Three substrates— carbohydrate, fat, protein
Substrates combines with OX to form…
ATP aerobically.
Oxidative Energy System occurs mostly in…
Type I and sometimes IIA fibers.
Number of Steps in ATP/PCR energy system
1 Step.
Number of steps in anerobic glycolysis + glycogenolysis
10 Steps.
Number of steps in oxidative energy system
Many steps, dependent on the substrate (CHO, fat, protein) catabolized.
Physical (health-related) fitness components:
Muscular strength + endurance, aerobic endurance, flexibility, body composition.
Performance-related (motor-skill) fitness components:
Speed, power, agility, coordination, balance, speed + power endurance.
ATP/PCr energy system intensity
Very high intensity (muscular strength, power, speed, agility).
Glycolytic energy system intensity
High intensity (muscular endurance, speed endurance, power endurance).
Oxidative energy system intensity
Low to moderate intensity (aerobic endurance).
General Adaptation Syndrome
Process that describes how the body responds to stress.
Specificity
Train for particular objective → particular adaptation.
Overload
Need stimulus greater than the muscle/body is used to.
Progression
As muscle adapts to new stimulus, periodically increase stimulus.
Strength-training requires…
<1.6 grams of protein per kg of body mass per day (1.6 g/kg/d) for optimal strength gains.
Neural disinhibition
Decreased sensitivity of Golgi Tendon Reflex (GTO kicks in at higher intensity, is able to recruit more type II motor units, increased ability to produce force).