Antipsychotic Drugs ONLY

FGAs

• MOA: block dopamine (D2) receptors

Low: “Cant Tell” if its low

• Chlorpromazine

• Thioridazine

Mild:

• Loxapine

• Perphenazine

High potency: Time To Have Fun

• Haloperiodol

• Fluphenazine

• Thiothixene

• Trifluoperazine

SGAs

• MOA: block both DA and 5-HT receptors; D2 and 5-HT2A antagonists

Basically anything that isnt FGA T_T

TD Treatment

• Valbenazine (Ingrezza)

• Deutetrabenazine (Austedo)

MOA: reversibly inhibits vesicular monoamine transporter 2 (VMAT2) → reduce reuptake of DA

Misc Agents

Xanomeline and Trospium Chloride (Cobenfy)

MOA: agonist activity at M1 and M4 receptors in brain

• Xanomeline: modulate pre-synaptic DA release

• Trospium chloride: antagonizes muscarinic receptors outside the brain, primarily in peripheral tissues