VZV vaccines

what does VZV cause

chickenpox and shingles

how does the rash spread in VZV

spreads to lymph notes and from blood to skin through infected T cells

how are T cells infected with VZV

transfer through respiratory epithelial cells and infection of dendritic cells that migrate to lymph nodes

VZV causes a reaction by infecting _________________ in _________________

sensory nerve bodes; dorsal root ganglia and trigeminal ganglia

where does zoster manifest

dermatome stimulated by ganglia

what do infected CD4 cells express

cutaneous leukocyte antigen and CCR4

when the virus is in the skin, what does it trigger

Type I IFNs and promyelocytic leukemia protein

what does PML do

forms intranucelar cages to wrap new virions

what is important for preventing the reactivation of VZV

memory T cells

what does the immune response to VZV stimulate

T cells and B cells

are B cells or T cells required for resolving VZV infections

both are required

true or false: you can get shingles more than once

true

what age should the varicella vaccine be given and why

12 months, maternal antibodies are high the first year of life and can clear out the virus

what protein does the shingrix vaccine have

gE

what is gE

surface protein on VZV

what do the antibodies against gE do

they are neutralizing and attachment and infection are blocked

what else was added in the shingrix vaccine in addition to gE and why

an adjuvant for further protection