Essay 4: Wound Repair

Wound Healing

The complex series of events that restore the protective barrier of the integumentary system and maintain homeostasis after skin injury.

Integumentary System

The organ system that includes the skin and its appendages, protecting the body from various damage.

Homeostasis

The process by which the body maintains a stable internal environment despite changes in external conditions.

Inflammation

The first stage of wound healing that begins immediately after injury, characterized by pain, redness, swelling, and heat.

Histamine

A chemical released by damaged tissues that causes vasodilation and increases blood flow to an injured area.

Vasodilation

The widening of blood vessels that increases blood flow to tissues.

Phagocytosis

The process by which white blood cells engulf and digest debris and bacteria.

Fibroblasts

Cells that migrate to the wound during the proliferative phase and produce collagen fibers and extracellular matrix.

Collagen Fibers

Protein fibers that provide structural support and strength to tissues.

Angiogenesis

The formation of new blood vessels to supply oxygen and nutrients to healing tissues.

Granulation Tissue

Pink, soft tissue that fills the wound area during healing and replaces the initial blood clot.

Keratinocytes

Cells that migrate across the wound surface during the proliferative phase to restore the epidermis.

Mitosis

The process of cell division that produces new cells, which in keratinocytes helps restore the skin.

Remodeling Phase

The final stage of wound healing where new tissue is strengthened and organized into a denser pattern.

Scar Formation

The process where repaired skin may lack original structures, resulting in a different appearance and texture.