Intro to Neuropharm Marijuana and Cannabinoids

metabatropic

Cannabinoid receptors are metabotropic or ionotropic?

CB1 Receptor

Principle cannabinoid receptor in the brain, also expressed in many other organisms

CB2 receptor

In immune system and brain - in microglia and neurons; ____ knockout mice show these receptors play a significant role in several behavioral functions

Presynaptic CB1

Receptors on nerve terminals have an inhibitory response on neurotransmitter release

rimonabant

CB1 antagonist drug used to study receptor function

reduced locomotor activity, hypothermia, catalepsy, and hypoalgesia

CB1 receptor mediated affects in THC mice

Cannabidiol (CBD)

Drug used as negative allosteric modulator of CB1 receptors?

Cannabidiol (CBD)

Inhibits breakdown of endogenous cannabinoids - enhances activity of the endocannabinoid system

endocannabinoids

_____________ are cannabinoid receptor agonists synthesized by the body

Anandamide and 2-AG

lipid soluble - can’t be stored in vesicles; synthesized and released when needed, triggered by a rise in intracellular Ca+2 levels

2-AG

Is a full agonist at CB1 and CB2

A-2: retrograde anandamide:non-retrograde

A-2 and anandamide are retrograde or non-retrograde signaling?

reduce food consumption

CB1 receptor antagonists reliably…?

dronabinol, nabiximols, epidiolex, and medical marijuana

What are the four therapeutic cannabinoids?

dronabinol

therapeutic drug that enhances appetite or combat nausea

nabiximols

Drug treatment for neuropathic pain and muscle spasticity in MS

Epidiolex

Drug treatment that reduces seizures in pediatric epilepsy