[BIO 120.3] Group 4 - Hepatitis

HBsAg

The lipid envelope of HBV contains what protein?

HBcAg

The inner nucleocapsid of HBV contains what portein?

Double stranded, circular DNA

Describe the genome of HBV

HBV

Which Hepa Virus/es has DNA as their genome?

HBV, HCV

Which Hepa Virus/es have enveloped capsids?

HAV (inactivated), HBV (recombinant)

Which Hepa Virus/es have vaccines?

HBx Protein

HBV Protein: Key for viral replication as it disrupts DNA repair and promotes protein degradation

HBx Protein

HBV Protein: Activates pathways for contributing to liver disease and HCC

HBsAg

HBV Protein: Surface antigens composed of L, M, S proteins that dive infectivity and immune evasion

NTCP receptor

HBV uses this receptor to enter liver cells and start infections

HBsAg

HBV Protein: Responsible for the Start phase of HBV pathogenesis

HBx

HBV Protein: Responsible for the replication phase of HBV pathogenesis

HBeAg

HBV Protein: Responsible for the IR Evasion phase of HBV pathogenesis

HBcAg

HBV Protein: Responsible for the Cytotoxicity phase of HBV pathogenesis

TRUE

T/F: Vertical transmission is the predominant mode of transmission for HBV

FALSE

T/F: Horizontal transmission is the predominant mode of transmission for HBV

TRUE

T/F: Chronic HBV mostly affects children less than 6 years old (95%)

FALSE

T/F: Chronic HBV mostly affects adults

Preicteric (4-12 weeks), Icteric (2 weeks - 3 months), Convalescence

What are the 3 Phases of HBV infection?

HBSAg Test

The most commonly used diagnostic tool for acute HBV infections or carriers.

TRUE

T/F: The onset of jaundice by HBV occurs in the icteric phase

FALSE

T/F: The onset of jaundice by HBV occurs in the preicteric phase

TRUE

T/F: In the HBSAg Test, if confirmed positive, they are also considered as contagious

FALSE

T/F: The HBsAg Test does not give only clues on how contagious a person is, it only confirms if someone is positive or negative for HBV

Anti-HBs

This diagnosis method for HBV tests not only for current, but also former HBV infection

Anti-HBs

This diagnosis method for HBV tests assesses the risk of perinatal HBV transmission and can detect occult HBV infection

HBeAg

marker linked to a high level of infectious HBV particles in the blood

TRUE

T/F: There is no specific therapy for acute HBV

FALSE

T/F: There is no specific therapy for acute and chronic HBV

Tenofovir, Entecavir

Oral medicines that serve as treatment for chronic HBV

Positive strand, RNA

Describe genome of HCV

VP7 and NS2

HCV Proteins: Essential for viral assembly and release

NS3

HCV Proteins: C-terminal region that contains the RNA helicase

NS5A

HCV Proteins: viral transcription and replication

Exposure to infectious blood

What is the primary transmission route for HCV?

TRUE

T/F: Vertical transmissions may occur for both HBV and HCV

FALSE

T/F: Vertical transmissions only occur for HBV

TRUE

T/F: there is a specific treatment for HCV

FALSE

T/F: there is no specific treatment for HCV

Pegylated IFN alpha, Ribavirin

What are the 2 treatments for HCV?

Achieved sustained virologic response, Prevent progression to liver damage

What are the 2 goals of HCV treatment?

IgM

What antibodies are detected in the blood for HAV diagnosis?

TRUE

T/F: There is no specific treatment for HAV

FALSE

T/F: There is a specific treatment against HAV

TRUE

T/F: For HAV, acetimanophen and paracetamol are not recommended

FALSE

T/F: For HAV, acetaminophen and paracetamol are recommended as there is no specific treatment for HAV

TRUE

T/F: For HAV, hospitalization is unnecessary for asymptomatic cases

FALSE

T/F: For HAV, hospitalization is still necessary for asymptomatic cases

Fecal-oral

What is the mode of transmission for HAV?

HBV

What Hepa Virus is the main cause of liver cancer?

HBV

What Hepa virus is usually considered as a coinfection with HDV?

HIV

What Hepa virus is usually considered as a coinfection with HIV?

TRUE

T/F: Sexual transmission of HCV is rare

FALSE

T/F: Sexual transmission of HCV is predominant